Modulation of mitoxantrone cytotoxicity by verapamil in human chronic myeloid leukemia cells

K. Satyamoorthy; M. P. Chitnis; S. G. Pradhan; S. H. Advani

doi:10.1159/000226699

Modulation of mitoxantrone cytotoxicity by verapamil in human chronic myeloid leukemia cells

K. Satyamoorthy, M. P. Chitnis, S. G. Pradhan, S. H. Advani

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Abstract

Calcium channel-blocking agent verapamil has been established to bean effective drug to modulate the action of many anticancer drugs. In this study, we examined the effect of verapamil on the cytotoxicity of mitoxantrone in human chronic myeloid leukemia (CML) cells. Mitoxantrone alone exhibited dose-dependent inhibition of DNA biosynthesis in CML cells. The addition of verapamil (3.3 μM) enhanced the responsiveness of CML cells to mitoxantrone (I μg/ml) cytotoxicity indicated by significant increased inhibition of thymidine incorporation (p < 0.001). The present study demonstrates the possible efficacy of verapamil in the chemotherapy of CML with mitoxantrone.

Original language	English
Pages (from-to)	128-131
Number of pages	4
Journal	Oncology (Switzerland)
Volume	46
Issue number	2
DOIs	https://doi.org/10.1159/000226699
Publication status	Published - 1989

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1159/000226699

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abstract = "Calcium channel-blocking agent verapamil has been established to bean effective drug to modulate the action of many anticancer drugs. In this study, we examined the effect of verapamil on the cytotoxicity of mitoxantrone in human chronic myeloid leukemia (CML) cells. Mitoxantrone alone exhibited dose-dependent inhibition of DNA biosynthesis in CML cells. The addition of verapamil (3.3 μM) enhanced the responsiveness of CML cells to mitoxantrone (I μg/ml) cytotoxicity indicated by significant increased inhibition of thymidine incorporation (p < 0.001). The present study demonstrates the possible efficacy of verapamil in the chemotherapy of CML with mitoxantrone.",

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AU - Advani, S. H.

PY - 1989

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AB - Calcium channel-blocking agent verapamil has been established to bean effective drug to modulate the action of many anticancer drugs. In this study, we examined the effect of verapamil on the cytotoxicity of mitoxantrone in human chronic myeloid leukemia (CML) cells. Mitoxantrone alone exhibited dose-dependent inhibition of DNA biosynthesis in CML cells. The addition of verapamil (3.3 μM) enhanced the responsiveness of CML cells to mitoxantrone (I μg/ml) cytotoxicity indicated by significant increased inhibition of thymidine incorporation (p < 0.001). The present study demonstrates the possible efficacy of verapamil in the chemotherapy of CML with mitoxantrone.

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Modulation of mitoxantrone cytotoxicity by verapamil in human chronic myeloid leukemia cells

Abstract

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