Moonlighting functions of the ubiquitin-like protein, Hub1/UBL-5

Kiran Kumar Kolathur; Sandeep Mallya; Shivmani Barve; Sree Lalitha Bojja; Manoj M. Wagle

doi:10.1016/j.biocel.2023.106445

Moonlighting functions of the ubiquitin-like protein, Hub1/UBL-5

Kiran Kumar Kolathur^*
, Sandeep Mallya
, Shivmani Barve
, Sree Lalitha Bojja
, Manoj M. Wagle

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The faithful splicing of pre-mRNA is critical for accurate gene expression. Dysregulation of pre-mRNA splicing has been associated with several human diseases including cancer. The ubiquitin-like protein Hub1/UBL5 binds to the substrates non-covalently and promotes pre-mRNA splicing. Additionally, UBL5 promotes the common fragile sites stability and the Fanconi anemia pathway of DNA damage repair. These functions strongly suggests that UBL5 could potentially be implicated in cancer. Therefore, we analyzed the UBL5 expression in TCGA tumor sample datasets and observed the differences between tumor and normal tissues among different tumor subtypes. We have noticed the alteration frequency of UBL5 in TCGA tumor samples. Altogether, this review summarizes the UBL5 functions and discusses its putative role in tumorigenesis.

Original language	English
Article number	106445
Journal	International Journal of Biochemistry and Cell Biology
Volume	162
DOIs	https://doi.org/10.1016/j.biocel.2023.106445
Publication status	Published - 09-2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Biochemistry
Cell Biology

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10.1016/j.biocel.2023.106445

Cite this

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title = "Moonlighting functions of the ubiquitin-like protein, Hub1/UBL-5",

abstract = "The faithful splicing of pre-mRNA is critical for accurate gene expression. Dysregulation of pre-mRNA splicing has been associated with several human diseases including cancer. The ubiquitin-like protein Hub1/UBL5 binds to the substrates non-covalently and promotes pre-mRNA splicing. Additionally, UBL5 promotes the common fragile sites stability and the Fanconi anemia pathway of DNA damage repair. These functions strongly suggests that UBL5 could potentially be implicated in cancer. Therefore, we analyzed the UBL5 expression in TCGA tumor sample datasets and observed the differences between tumor and normal tissues among different tumor subtypes. We have noticed the alteration frequency of UBL5 in TCGA tumor samples. Altogether, this review summarizes the UBL5 functions and discusses its putative role in tumorigenesis.",

author = "Kolathur, \{Kiran Kumar\} and Sandeep Mallya and Shivmani Barve and Bojja, \{Sree Lalitha\} and Wagle, \{Manoj M.\}",

note = "Funding Information: This work was supported by Manipal Centre for Infectious Diseases (MAC-ID), MAHE, Manipal ( MAC ID/SGA/2023/102 ). Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

year = "2023",

month = sep,

doi = "10.1016/j.biocel.2023.106445",

language = "English",

volume = "162",

journal = "International Journal of Biochemistry and Cell Biology",

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AU - Kolathur, Kiran Kumar

AU - Mallya, Sandeep

AU - Barve, Shivmani

AU - Bojja, Sree Lalitha

AU - Wagle, Manoj M.

PY - 2023/9

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N2 - The faithful splicing of pre-mRNA is critical for accurate gene expression. Dysregulation of pre-mRNA splicing has been associated with several human diseases including cancer. The ubiquitin-like protein Hub1/UBL5 binds to the substrates non-covalently and promotes pre-mRNA splicing. Additionally, UBL5 promotes the common fragile sites stability and the Fanconi anemia pathway of DNA damage repair. These functions strongly suggests that UBL5 could potentially be implicated in cancer. Therefore, we analyzed the UBL5 expression in TCGA tumor sample datasets and observed the differences between tumor and normal tissues among different tumor subtypes. We have noticed the alteration frequency of UBL5 in TCGA tumor samples. Altogether, this review summarizes the UBL5 functions and discusses its putative role in tumorigenesis.

AB - The faithful splicing of pre-mRNA is critical for accurate gene expression. Dysregulation of pre-mRNA splicing has been associated with several human diseases including cancer. The ubiquitin-like protein Hub1/UBL5 binds to the substrates non-covalently and promotes pre-mRNA splicing. Additionally, UBL5 promotes the common fragile sites stability and the Fanconi anemia pathway of DNA damage repair. These functions strongly suggests that UBL5 could potentially be implicated in cancer. Therefore, we analyzed the UBL5 expression in TCGA tumor sample datasets and observed the differences between tumor and normal tissues among different tumor subtypes. We have noticed the alteration frequency of UBL5 in TCGA tumor samples. Altogether, this review summarizes the UBL5 functions and discusses its putative role in tumorigenesis.

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Moonlighting functions of the ubiquitin-like protein, Hub1/UBL-5

Abstract

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