TY - JOUR
T1 - Morphometric evaluation of endometrial blood vessels
AU - Makhija, Divya
AU - Mathai, Alka
AU - Naik, Ramadas
AU - Kumar, Suneet
AU - Rai, Sharada
AU - Pai, Muktha
AU - Baliga, Poornima
PY - 2008/7/1
Y1 - 2008/7/1
N2 - Five hundred endometrial specimens were studied to document the changes in blood vessels in various phases of menstrual cycle, menstrual disturbances and in unexplained infertility. Sixty-three cases were taken as control and 437 cases as study group which included cases of dysfunctional uterine bleeding (DUB), endometrial polyps, fibroids, adenomyosis, infertility and atrophic endometrium. Using light microscopy, the vascular morphology was studied. The blood vessels were concentrated more in basal layer in the proliferative phase and in functional layer in the secretory phase. Cases of complex hyperplasia and pill endometrium had significantly higher vessel concentration. Congestion and dilatation of blood vessels were significantly higher in cases of DUB. The present study showed a positive correlation between endometrial angiogenesis and menstrual disorders. The alteration in blood vessel morphology has significant role in prognosis and in various anti-angiogenic therapies.
AB - Five hundred endometrial specimens were studied to document the changes in blood vessels in various phases of menstrual cycle, menstrual disturbances and in unexplained infertility. Sixty-three cases were taken as control and 437 cases as study group which included cases of dysfunctional uterine bleeding (DUB), endometrial polyps, fibroids, adenomyosis, infertility and atrophic endometrium. Using light microscopy, the vascular morphology was studied. The blood vessels were concentrated more in basal layer in the proliferative phase and in functional layer in the secretory phase. Cases of complex hyperplasia and pill endometrium had significantly higher vessel concentration. Congestion and dilatation of blood vessels were significantly higher in cases of DUB. The present study showed a positive correlation between endometrial angiogenesis and menstrual disorders. The alteration in blood vessel morphology has significant role in prognosis and in various anti-angiogenic therapies.
UR - http://www.scopus.com/inward/record.url?scp=50149092024&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=50149092024&partnerID=8YFLogxK
U2 - 10.4103/0377-4929.42508
DO - 10.4103/0377-4929.42508
M3 - Article
C2 - 18723955
AN - SCOPUS:50149092024
SN - 0377-4929
VL - 51
SP - 346
EP - 350
JO - Indian Journal of Pathology and Microbiology
JF - Indian Journal of Pathology and Microbiology
IS - 3
ER -