Morphometric evaluation of endometrial blood vessels

Divya Makhija, Alka Mathai, Ramadas Naik, Suneet Kumar, Sharada Rai, Muktha Pai, Poornima Baliga

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Five hundred endometrial specimens were studied to document the changes in blood vessels in various phases of menstrual cycle, menstrual disturbances and in unexplained infertility. Sixty-three cases were taken as control and 437 cases as study group which included cases of dysfunctional uterine bleeding (DUB), endometrial polyps, fibroids, adenomyosis, infertility and atrophic endometrium. Using light microscopy, the vascular morphology was studied. The blood vessels were concentrated more in basal layer in the proliferative phase and in functional layer in the secretory phase. Cases of complex hyperplasia and pill endometrium had significantly higher vessel concentration. Congestion and dilatation of blood vessels were significantly higher in cases of DUB. The present study showed a positive correlation between endometrial angiogenesis and menstrual disorders. The alteration in blood vessel morphology has significant role in prognosis and in various anti-angiogenic therapies.

Original languageEnglish
Pages (from-to)346-350
Number of pages5
JournalIndian Journal of Pathology and Microbiology
Issue number3
Publication statusPublished - 01-07-2008

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Microbiology (medical)


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