Multimodal phototherapy for Glioblastoma: from mechanistic action to synergistic delivery and therapeutic strategies

Gaurisha Alias Resha Ramnath Naik; Deepanjan Datta; Ritu Kudarha; Bhupendra Prajapati; Mital Patel; Varadharajan Srinivasan; Namdev Dhas

doi:10.1186/s12951-026-04441-y

Multimodal phototherapy for Glioblastoma: from mechanistic action to synergistic delivery and therapeutic strategies

Gaurisha Alias Resha Ramnath Naik
, Deepanjan Datta
, Ritu Kudarha
, Bhupendra Prajapati
, Mital Patel
, Varadharajan Srinivasan
, Namdev Dhas^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Phototherapy offers targeted, minimally invasive treatment for glioblastoma (GBM) with reduced systemic toxicity. Intranasal delivery bypasses the blood-brain barrier (BBB) but requires improved tumor targeting and synchronized light activation. Recent advancements in nanotechnology and smart photosensitizers have improved the selectivity and efficacy of PDT and PTT. Key challenges for GBM phototherapy include light penetration and drug retention. The future of GBM treatment may rely on combining phototherapy with personalized methods and collaborative research.

Original language	English
Article number	539
Journal	Journal of Nanobiotechnology
Volume	24
Issue number	1
DOIs	https://doi.org/10.1186/s12951-026-04441-y
Publication status	Published - 12-2026

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)
Bioengineering
Applied Microbiology and Biotechnology
Molecular Medicine
Biomedical Engineering
Pharmaceutical Science

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10.1186/s12951-026-04441-y

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title = "Multimodal phototherapy for Glioblastoma: from mechanistic action to synergistic delivery and therapeutic strategies",

abstract = "Phototherapy offers targeted, minimally invasive treatment for glioblastoma (GBM) with reduced systemic toxicity. Intranasal delivery bypasses the blood-brain barrier (BBB) but requires improved tumor targeting and synchronized light activation. Recent advancements in nanotechnology and smart photosensitizers have improved the selectivity and efficacy of PDT and PTT. Key challenges for GBM phototherapy include light penetration and drug retention. The future of GBM treatment may rely on combining phototherapy with personalized methods and collaborative research.",

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AU - Naik, Gaurisha Alias Resha Ramnath

AU - Datta, Deepanjan

AU - Kudarha, Ritu

AU - Prajapati, Bhupendra

AU - Patel, Mital

AU - Srinivasan, Varadharajan

AU - Dhas, Namdev

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N2 - Phototherapy offers targeted, minimally invasive treatment for glioblastoma (GBM) with reduced systemic toxicity. Intranasal delivery bypasses the blood-brain barrier (BBB) but requires improved tumor targeting and synchronized light activation. Recent advancements in nanotechnology and smart photosensitizers have improved the selectivity and efficacy of PDT and PTT. Key challenges for GBM phototherapy include light penetration and drug retention. The future of GBM treatment may rely on combining phototherapy with personalized methods and collaborative research.

AB - Phototherapy offers targeted, minimally invasive treatment for glioblastoma (GBM) with reduced systemic toxicity. Intranasal delivery bypasses the blood-brain barrier (BBB) but requires improved tumor targeting and synchronized light activation. Recent advancements in nanotechnology and smart photosensitizers have improved the selectivity and efficacy of PDT and PTT. Key challenges for GBM phototherapy include light penetration and drug retention. The future of GBM treatment may rely on combining phototherapy with personalized methods and collaborative research.

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M1 - 539

ER -

Multimodal phototherapy for Glioblastoma: from mechanistic action to synergistic delivery and therapeutic strategies

Abstract

All Science Journal Classification (ASJC) codes

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