N-[(2′-cyanobiphenyl-4-yl)methyl]-L-valine methyl ester hydrochloride: An intermediate in the synthesis of valsartan

Hemmige S. Yathirajan; Basavegowda Nagaraj; Santhosh L. Gaonkar; Rajenahally S. Narasegowda; Padmarajaiah Nagaraja; Basappa Prabhuswamy; Michael Bolte

doi:10.1107/S1600536804026790

N-[(2′-cyanobiphenyl-4-yl)methyl]-L-valine methyl ester hydrochloride: An intermediate in the synthesis of valsartan

Hemmige S. Yathirajan
, Basavegowda Nagaraj
, Santhosh L. Gaonkar
, Rajenahally S. Narasegowda
, Padmarajaiah Nagaraja
, Basappa Prabhuswamy
, Michael Bolte^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The title compound {systematic name: methyl 2-[(2′-cyanobiphenyl-4-yl)methylammonio]-3-methylbutanoate chloride), C₂₀H₂₃N₂O²⁺·Cl^-, is a key intermediate in the synthesis of valsartan. It crystallizes with two ion pairs in the asymmetric unit, related pseudocentrosymmetrically to each other. The two cations differ only in the orientation of the isopropyl group.

Original language	English
Pages (from-to)	o2160-o2162
Journal	Acta Crystallographica Section E: Structure Reports Online
Volume	60
Issue number	11
DOIs	https://doi.org/10.1107/S1600536804026790
Publication status	Published - 11-2004

All Science Journal Classification (ASJC) codes

General Chemistry
General Materials Science
Condensed Matter Physics

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title = "N-[(2′-cyanobiphenyl-4-yl)methyl]-L-valine methyl ester hydrochloride: An intermediate in the synthesis of valsartan",

abstract = "The title compound \{systematic name: methyl 2-[(2′-cyanobiphenyl-4-yl)methylammonio]-3-methylbutanoate chloride), C20H23N2O2+·Cl-, is a key intermediate in the synthesis of valsartan. It crystallizes with two ion pairs in the asymmetric unit, related pseudocentrosymmetrically to each other. The two cations differ only in the orientation of the isopropyl group.",

author = "Yathirajan, \{Hemmige S.\} and Basavegowda Nagaraj and Gaonkar, \{Santhosh L.\} and Narasegowda, \{Rajenahally S.\} and Padmarajaiah Nagaraja and Basappa Prabhuswamy and Michael Bolte",

year = "2004",

month = nov,

doi = "10.1107/S1600536804026790",

language = "English",

volume = "60",

pages = "o2160--o2162",

journal = "Acta Crystallographica Section E: Structure Reports Online",

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TY - JOUR

T1 - N-[(2′-cyanobiphenyl-4-yl)methyl]-L-valine methyl ester hydrochloride

T2 - An intermediate in the synthesis of valsartan

AU - Yathirajan, Hemmige S.

AU - Nagaraj, Basavegowda

AU - Gaonkar, Santhosh L.

AU - Narasegowda, Rajenahally S.

AU - Nagaraja, Padmarajaiah

AU - Prabhuswamy, Basappa

AU - Bolte, Michael

PY - 2004/11

Y1 - 2004/11

N2 - The title compound {systematic name: methyl 2-[(2′-cyanobiphenyl-4-yl)methylammonio]-3-methylbutanoate chloride), C20H23N2O2+·Cl-, is a key intermediate in the synthesis of valsartan. It crystallizes with two ion pairs in the asymmetric unit, related pseudocentrosymmetrically to each other. The two cations differ only in the orientation of the isopropyl group.

AB - The title compound {systematic name: methyl 2-[(2′-cyanobiphenyl-4-yl)methylammonio]-3-methylbutanoate chloride), C20H23N2O2+·Cl-, is a key intermediate in the synthesis of valsartan. It crystallizes with two ion pairs in the asymmetric unit, related pseudocentrosymmetrically to each other. The two cations differ only in the orientation of the isopropyl group.

UR - https://www.scopus.com/pages/publications/18544389506

UR - https://www.scopus.com/pages/publications/18544389506#tab=citedBy

U2 - 10.1107/S1600536804026790

DO - 10.1107/S1600536804026790

M3 - Article

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SN - 1600-5368

VL - 60

SP - o2160-o2162

JO - Acta Crystallographica Section E: Structure Reports Online

JF - Acta Crystallographica Section E: Structure Reports Online

IS - 11

ER -

N-[(2′-cyanobiphenyl-4-yl)methyl]-L-valine methyl ester hydrochloride: An intermediate in the synthesis of valsartan

Abstract

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