N-terminal-pro brain natriuretic peptide in assessing the severity of stable coronary artery disease

Vijetha Shenoy Belle, R. V.Krishnananda Prabhu, Ranjan K. Shetty, Rajaram Prasad, Pragna Rao, Asha Kamath, Kriti Singh, Priyanka Datta

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Introduction: Coronary Artery Disease (CAD) occurs due to atherosclerosis which results in progressive narrowing of coronary artery lumen. N-Terminal pro Brain Natriuretic Peptide (NT-proBNP) has been used as a marker of heart failure. However, its role in stable coronary artery disease without left ventricular dysfunction is limited. Aim: To measure and compare the serum NT-proBNP levels in stable coronary artery patients and controls and to correlate serum NT-proBNP levels with severity of CAD. Materials and Methods: The present study was conducted in Department of Biochemistry in collaboration with Department of Cardiology Kasturba Medical College, Manipal after the approval from Institutional Ethics Committee. A written consent was obtained from 86 study subjects (controls 36, cases 50). Serum NT-proBNP was measured using ELISA kit. Severity of CAD was graded by angiogram based Gensini scoring system. Mann-Whitney U-tests and spearman’s correlations were used. Serum NT-proBNP was expressed in median and interquartile range. The p-value<0.05 was considered to be significant. Results: Median values of serum NT-proBNP levels in cases (151.9 pg/mL) were significantly higher as compared to that of controls (99.31 pg/mL), (p<0.001). There was a significant positive correlation of serum NT-proBNP with the respective Gensini scores in patients with stable coronary artery disease (r=0.263, p=0.014). Conclusion: As Serum NT-proBNP levels were significantly associated with severity of stable CAD without left ventricular dysfunction, it can be a potential tool in effective management of stable CAD.

Original languageEnglish
Pages (from-to)BC25-BC28
JournalJournal of Clinical and Diagnostic Research
Issue number8
Publication statusPublished - 01-08-2018

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry


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