Nanosponges: Advancement in Nanotherapeutics

Natasha Verma, Annamalai Rama, Adrija Jha, Bhautik Ladani, Induja Govindan, Sivakumar Kannan, Srinivas Hebbar, Anup Naha

Research output: Contribution to journalReview articlepeer-review


The emergence of nanotechnology paves the way for improving disease therapy strategies. An investigation into the progression of the release of the medication targeting the specified predetermined location is a significant factor to consider. Due to the ability to advance existing products and to develop new products in a variety of applications, the nanotechnology industry is considered an evolving technology. Cyclodextrin-based porous nanoparticles or unique nano-sponges (NSs) which have recently been used in the pharmaceutical, biomedical, and cosmetic industries are the main elements of this growth. This superior technology can circumvent the defects of current techniques by its ability to attack and visualize tumour sites. A biodegradable and biocompatible feature along with a built-in high surface area resulting in enormous amounts of drug loading and biomimetic design, and the ability to control nanoparticles size are just a handful of good attractive attributes that find this technique as an overwhelming advantage in the field of nanomedicine. This review article is organized such that we first explored the unique features of these nanosponges and the diverse methods for synthesizing, followed by the drug loading and release principle and application based on drug delivery, targeting, boosting solubility of BCS Class II and IV drugs, others in biomedicine and more. Finally, the recent progress on the use of biomimetic nanosponge as a pandemic tool due to the SARS-CoV-2 virus briefly comes into line.

Original languageEnglish
Pages (from-to)4253-4260
Number of pages8
JournalResearch Journal of Pharmacy and Technology
Issue number9
Publication statusPublished - 09-2022

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
  • Pharmacology (medical)


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