TY - JOUR
T1 - Naringin and naringenin inhibit nitrite-induced methemoglobin formation
AU - Kumar, M.S.
AU - Unnikrishnan, M.K.
AU - Patra, S.
AU - Murthy, K.
AU - Srinivasan, K.K.
N1 - Cited By :23
Export Date: 10 November 2017
CODEN: PHARA
Correspondence Address: Kumar, M.S.; Department of Pharmacology, College of Pharmaceutical Sciences, Manipal - 576119, India; email: [email protected]
Chemicals/CAS: aurantiin, 10236-47-2, 12619-61-3, 29658-83-1, 82350-96-7; curcumin, 458-37-7; naringenin, 480-41-1, 67604-48-2; nitrite, 14797-65-0; superoxide, 11062-77-4; Antioxidants; Flavanones; Flavonoids; Free Radical Scavengers; Methemoglobin, 9008-37-1; naringenin, 480-41-1; naringin, 10236-47-2; Nitrites
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PY - 2003
Y1 - 2003
N2 - Naringin and naringenin protect hemoglobin from nitrite-induced oxidation to methemoglobin. The protection is not observed when naringin and naringenin are added after the autocatalytic stage of the oxidation of hemoglobin by nitrite. The ability of naringin and naringenin to scavenge oxygen free radicals may be responsible for the action because superoxide, hydroxyl and other free radicals are implicated in promoting the autocatalytic stage of oxidation of hemoglobin by nitrite. Both compounds showed less ability to protect intact erythrocytes suggesting that they may not cross the erythrocyte membrane in sufficient amounts. Naringenin was more effective than naringin, probably because of the extra phenolic group in the aglycone.
AB - Naringin and naringenin protect hemoglobin from nitrite-induced oxidation to methemoglobin. The protection is not observed when naringin and naringenin are added after the autocatalytic stage of the oxidation of hemoglobin by nitrite. The ability of naringin and naringenin to scavenge oxygen free radicals may be responsible for the action because superoxide, hydroxyl and other free radicals are implicated in promoting the autocatalytic stage of oxidation of hemoglobin by nitrite. Both compounds showed less ability to protect intact erythrocytes suggesting that they may not cross the erythrocyte membrane in sufficient amounts. Naringenin was more effective than naringin, probably because of the extra phenolic group in the aglycone.
M3 - Article
SN - 0031-7144
VL - 58
SP - 564
EP - 566
JO - Pharmazie
JF - Pharmazie
IS - 8
ER -