Nasal Polyposis in mucopolysaccharidosis type II

Sushmitha Kabekkodu, Suja Sreedharan, Kirti Gupta, Nirupama Murali

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Mucopolysaccharidosis (MPS) type II is a rare multisystem disorder resulting from the accumulation of breakdown products of glycosaminoglycans in the body tissues. Many patients with this disease undergo ENT (ear, nose and throat) surgeries such as adenotonsillectomy and tympanocentesis at a very early age, much before the diagnosis of MPS. Nasal polyposis is a rare occurrence, with only one case of MPS II with polyposis reported in the literature. We present a patient who presented with recurrent nasal polyposis from the age of 2 years. Hale's colloidal iron was used to stain these â € nasal polyps', which revealed that they are, in fact, mucopolysaccharide-laden sinonasal mucosa prolapsing into the nasal cavities. We believe this is the first time that this stain has been used to stain nasal polyps in MPS. In addition to the histopathological peculiarities of these nasal masses, we also discuss the natural history of nasal polyposis in MPS II.

Original languageEnglish
Article numbere238778
JournalBMJ Case Reports
Issue number3
Publication statusPublished - 05-03-2021

All Science Journal Classification (ASJC) codes

  • General Medicine


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