TY - JOUR
T1 - Neonatal outcomes associated with antimicrobial resistance
T2 - A retrospective cross-sectional study
AU - Chandra, Prashant
AU - Iqbal, Faiza
AU - Unnikrisnan, Mazhuvancherry Kesavan
AU - Jayashree, Purkayastha
AU - Shenoy, Padmaja A.
AU - Anburaj, Stanly Elstin
AU - Rajesh, Vilakkathala
AU - Surulivelrajan, Mallayasamy
AU - Lewis, Leslie Edward
N1 - Publisher Copyright:
© 2023 Prashant Chandra et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/)
PY - 2023/5
Y1 - 2023/5
N2 - Neonatal sepsis (NS) is a leading cause of morbidity and mortality requiring immediate admission and prolonged neonatal intensive care unit (NICU) stay. This study attempts to identify factors associated with NS and its outcomes. A total of 186 NS cases records (January 2017 to September 2019) were analyzed retrospectively. Multiple logistic regression and linear regression were employed to determine the factors associated with mortality, length of NICU stay, and treatment cost with a significance level of p ≤ 0.05. The mean neonatal age was 6.8 ± 9.5 days. Culture reports identified Klebsiella pneumonia (69%) as the major pathogen. Forty-four percent of neonates died, of whom 57% and 44% suffered early-onset sepsis and late-onset sepsis respectively. Logistic regression showed that mortality was significantly associated with platelet count (OR = 0.998; 95% CI =0.996–1.000) and very low birth weight (LBW) (OR = 2.427; 95% CI = 1.103–5.342). Linear regression showed that the number of definitive antibiotics used was associated with prolonged length of NICU stay. Also, length of NICU stay, number of definitive antibiotics, seizures, and heart disease, were significantly associated with overall cost. Mortality was higher with early-onset of sepsis than with late-onset of sepsis.
AB - Neonatal sepsis (NS) is a leading cause of morbidity and mortality requiring immediate admission and prolonged neonatal intensive care unit (NICU) stay. This study attempts to identify factors associated with NS and its outcomes. A total of 186 NS cases records (January 2017 to September 2019) were analyzed retrospectively. Multiple logistic regression and linear regression were employed to determine the factors associated with mortality, length of NICU stay, and treatment cost with a significance level of p ≤ 0.05. The mean neonatal age was 6.8 ± 9.5 days. Culture reports identified Klebsiella pneumonia (69%) as the major pathogen. Forty-four percent of neonates died, of whom 57% and 44% suffered early-onset sepsis and late-onset sepsis respectively. Logistic regression showed that mortality was significantly associated with platelet count (OR = 0.998; 95% CI =0.996–1.000) and very low birth weight (LBW) (OR = 2.427; 95% CI = 1.103–5.342). Linear regression showed that the number of definitive antibiotics used was associated with prolonged length of NICU stay. Also, length of NICU stay, number of definitive antibiotics, seizures, and heart disease, were significantly associated with overall cost. Mortality was higher with early-onset of sepsis than with late-onset of sepsis.
UR - https://www.scopus.com/pages/publications/85159155722
UR - https://www.scopus.com/inward/citedby.url?scp=85159155722&partnerID=8YFLogxK
U2 - 10.7324/JAPS.2023.120166
DO - 10.7324/JAPS.2023.120166
M3 - Article
AN - SCOPUS:85159155722
SN - 2231-3354
VL - 13
SP - 81
EP - 94
JO - Journal of Applied Pharmaceutical Science
JF - Journal of Applied Pharmaceutical Science
IS - 5
ER -