TY - JOUR
T1 - Neurological manifestations of Kyasanur Forest disease
T2 - a retrospective cohort study from South India
AU - Gupta, Nitin
AU - Nallapati, Vishnu Teja
AU - Chunduru, Kiran
AU - Vithivattical, Alphy Rose James
AU - Kadavigere, Rajagopal
AU - Saravu, Kavitha
N1 - Publisher Copyright:
© The Author(s) 2022. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.
PY - 2022/10/2
Y1 - 2022/10/2
N2 - BACKGROUND: Kyasanur Forest disease (KFD) is a viral zoonotic disease where patients present with febrile illness and haemorrhagic manifestations in the first phase. In a small fraction of patients, the fever may be biphasic. This study aimed to describe the neurological manifestations of patients with KFD in the first and second phases of the illness. METHODS: This is a retrospective cohort study of 297 patients admitted with a molecular diagnosis of KFD from December 2018 to December 2020. The case records of these patients were reviewed for evidence of neurological involvement. RESULTS: A total of 34 (11.5%) patients in the first phase and 16 (36.4%) patients in the second phase had neurological involvement. Altered sensorium, seizures and focal infarcts were common in the first phase, while cerebellar signs and leptomeningeal enhancement were common in the second phase. CONCLUSIONS: Neurological involvement is seen in both phases of KFD. While in the first phase it is a result of possible encephalitis/encephalopathy, the second phase involvement is possibly due to postinfectious cerebellitis or meningitis.
AB - BACKGROUND: Kyasanur Forest disease (KFD) is a viral zoonotic disease where patients present with febrile illness and haemorrhagic manifestations in the first phase. In a small fraction of patients, the fever may be biphasic. This study aimed to describe the neurological manifestations of patients with KFD in the first and second phases of the illness. METHODS: This is a retrospective cohort study of 297 patients admitted with a molecular diagnosis of KFD from December 2018 to December 2020. The case records of these patients were reviewed for evidence of neurological involvement. RESULTS: A total of 34 (11.5%) patients in the first phase and 16 (36.4%) patients in the second phase had neurological involvement. Altered sensorium, seizures and focal infarcts were common in the first phase, while cerebellar signs and leptomeningeal enhancement were common in the second phase. CONCLUSIONS: Neurological involvement is seen in both phases of KFD. While in the first phase it is a result of possible encephalitis/encephalopathy, the second phase involvement is possibly due to postinfectious cerebellitis or meningitis.
UR - http://www.scopus.com/inward/record.url?scp=85139535506&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85139535506&partnerID=8YFLogxK
U2 - 10.1093/trstmh/trac018
DO - 10.1093/trstmh/trac018
M3 - Article
C2 - 35355076
AN - SCOPUS:85139535506
SN - 0035-9203
VL - 116
SP - 944
EP - 948
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
IS - 10
ER -
