Nimesulide dispersible tablets from 'direct compression' method

Direct compression, which is the method of choice in tablet manufacture to produce high quality of finished product, has been applied to prepare dispersible tablets of nimesulide. Nimesulide was subjected to preformulation studies to test the suitability of direct compression method and appropriate formulations were developed. These formulations were further evaluated for hardness, friability, weight variation, uniformity of dispersion, drug content, disintegration tests, in vitro dissolution rate and stability studies. Attempts were made to get minimum possible disintegration time by varying the concentrations of sodium starch glycolate and starch. Usage of mixture of both the disintegrants was found to be highly beneficial in the preparation of dispersible tablets of nimesulide.