NMR meets Tau: Insights into its function and pathology

Guy Lippens; Isabelle Landrieu; Caroline Smet; Isabelle Huvent; Neha S. Gandhi; Benoît Gigant; Clément Despres; Haoling Qi; Juan Lopez

doi:10.3390/biom6020028

NMR meets Tau: Insights into its function and pathology

Guy Lippens^*, Isabelle Landrieu, Caroline Smet, Isabelle Huvent, Neha S. Gandhi, Benoît Gigant, Clément Despres, Haoling Qi, Juan Lopez

^*Corresponding author for this work

School of Computer Engineering

Research output: Contribution to journal › Review article › peer-review

26 Citations (Scopus)

Abstract

In this review, we focus on what we have learned from Nuclear Magnetic Resonance (NMR) studies on the neuronal microtubule-associated protein Tau. We consider both the mechanistic details of Tau: the tubulin relationship and its aggregation process. Phosphorylation of Tau is intimately linked to both aspects. NMR spectroscopy has depicted accurate phosphorylation patterns by different kinases, and its non-destructive character has allowed functional assays with the same samples. Finally, we will discuss other post-translational modifications of Tau and its interaction with other cellular factors in relationship to its (dys)function.

Original language	English
Article number	28
Journal	Biomolecules
Volume	6
Issue number	2
DOIs	https://doi.org/10.3390/biom6020028
Publication status	Published - 06-2016

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology

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title = "NMR meets Tau: Insights into its function and pathology",

abstract = "In this review, we focus on what we have learned from Nuclear Magnetic Resonance (NMR) studies on the neuronal microtubule-associated protein Tau. We consider both the mechanistic details of Tau: the tubulin relationship and its aggregation process. Phosphorylation of Tau is intimately linked to both aspects. NMR spectroscopy has depicted accurate phosphorylation patterns by different kinases, and its non-destructive character has allowed functional assays with the same samples. Finally, we will discuss other post-translational modifications of Tau and its interaction with other cellular factors in relationship to its (dys)function.",

author = "Guy Lippens and Isabelle Landrieu and Caroline Smet and Isabelle Huvent and Gandhi, \{Neha S.\} and Beno{\^i}t Gigant and Cl{\'e}ment Despres and Haoling Qi and Juan Lopez",

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T2 - Insights into its function and pathology

AU - Lippens, Guy

AU - Landrieu, Isabelle

AU - Smet, Caroline

AU - Huvent, Isabelle

AU - Gandhi, Neha S.

AU - Gigant, Benoît

AU - Despres, Clément

AU - Qi, Haoling

AU - Lopez, Juan

PY - 2016/6

Y1 - 2016/6

N2 - In this review, we focus on what we have learned from Nuclear Magnetic Resonance (NMR) studies on the neuronal microtubule-associated protein Tau. We consider both the mechanistic details of Tau: the tubulin relationship and its aggregation process. Phosphorylation of Tau is intimately linked to both aspects. NMR spectroscopy has depicted accurate phosphorylation patterns by different kinases, and its non-destructive character has allowed functional assays with the same samples. Finally, we will discuss other post-translational modifications of Tau and its interaction with other cellular factors in relationship to its (dys)function.

AB - In this review, we focus on what we have learned from Nuclear Magnetic Resonance (NMR) studies on the neuronal microtubule-associated protein Tau. We consider both the mechanistic details of Tau: the tubulin relationship and its aggregation process. Phosphorylation of Tau is intimately linked to both aspects. NMR spectroscopy has depicted accurate phosphorylation patterns by different kinases, and its non-destructive character has allowed functional assays with the same samples. Finally, we will discuss other post-translational modifications of Tau and its interaction with other cellular factors in relationship to its (dys)function.

UR - https://www.scopus.com/pages/publications/85012081754

UR - https://www.scopus.com/inward/citedby.url?scp=85012081754&partnerID=8YFLogxK

U2 - 10.3390/biom6020028

DO - 10.3390/biom6020028

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AN - SCOPUS:85012081754

SN - 2218-273X

VL - 6

JO - Biomolecules

JF - Biomolecules

IS - 2

M1 - 28

ER -

NMR meets Tau: Insights into its function and pathology

Abstract

All Science Journal Classification (ASJC) codes

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