Novel chromeno [2,3-b]-pyrimidine derivatives as potential anti-microbial agents

U. Sankappa Rai, Arun M. Isloor, Prakash shetty, A. M. Vijesh, Nithin Prabhu, Shrikrishna Isloor, M. Thiageeswaran, Hoong Kun Fun

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)


An efficient, microwave irradiated synthesis of novel chromeno[2,3-b]-pyrimidine derivatives was carried out. 2-Amino-3,4-dihydro-2H-chromene-3-carbonitrile was converted into imine using N,N-Dimethylacetaldehyde dimethylacetal to give the core intermediate, which was used for the preparation of chromenopyrimidine library, using acetic acid and different amine in microwave irradiation for 5 min. Structures of newly synthesized compounds were confirmed by spectral studies. Compound 6g was characterized by single crystal X-ray analysis. All the compounds were also screened for their anti-microbial activity. Few of the compounds are found to be potential antimicrobials.

Original languageEnglish
Pages (from-to)2695-2699
Number of pages5
JournalEuropean Journal of Medicinal Chemistry
Issue number6
Publication statusPublished - 01-06-2010

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry


Dive into the research topics of 'Novel chromeno [2,3-b]-pyrimidine derivatives as potential anti-microbial agents'. Together they form a unique fingerprint.

Cite this