Novel Hypertrophic Cardiomyopathy Diagnosis Index Using Deep Features and Local Directional Pattern Techniques

Anjan Gudigar, U. Raghavendra, Jyothi Samanth, Chinmay Dharmik, Mokshagna Rohit Gangavarapu, Krishnananda Nayak, Edward J. Ciaccio, Ru San Tan, Filippo Molinari, U. Rajendra Acharya

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Hypertrophic cardiomyopathy (HCM) is a genetic disorder that exhibits a wide spectrum of clinical presentations, including sudden death. Early diagnosis and intervention may avert the latter. Left ventricular hypertrophy on heart imaging is an important diagnostic criterion for HCM, and the most common imaging modality is heart ultrasound (US). The US is operator-dependent, and its interpretation is subject to human error and variability. We proposed an automated computer-aided diagnostic tool to discriminate HCM from healthy subjects on US images. We used a local directional pattern and the ResNet-50 pretrained network to classify heart US images acquired from 62 known HCM patients and 101 healthy subjects. Deep features were ranked using Student’s t-test, and the most significant feature (SigFea) was identified. An integrated index derived from the simulation was defined as 100·log10 (SigFea/ √ 2) in each subject, and a diagnostic threshold value was empirically calculated as the mean of the minimum and maximum integrated indices among HCM and healthy subjects, respectively. An integrated index above a threshold of 0.5 separated HCM from healthy subjects with 100% accuracy in our test dataset.

Original languageEnglish
Article number102
JournalJournal of Imaging
Issue number4
Publication statusPublished - 04-2022

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Computer Vision and Pattern Recognition
  • Computer Graphics and Computer-Aided Design
  • Electrical and Electronic Engineering


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