Nutritional status in tuberculosis: A comprehensive problem to be addressed

Levin Thomas, Tejaswini Baral, Sonal Sekhar Miraj, Muralidhar Varma, B. Shrikar Reddy, Murali Munisamy, Karma Gurmey Dolma, Prakash Koirala, Rinchen Doma Bhutia, Bidita Khandelwal, Mahadev Rao

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Poor nutritional status is a significant risk factor for tuberculosis (TB) development, and TB can also cause nutritional deficiencies. Knowledge of this bidirectional relationship between nutrition and tuberculosis is primarily based on epidemiological studies. However, significant discrepancies exist in the literature, often due to the lack of high-quality data leading to inadequate exploration of clinical benefits of nutritional supplementation on TB outcomes. Additionally, malnutrition remains one of the biggest unaddressed confounders in most TB immunology and vaccinology studies conducted in TB endemic areas. As TB is intimately associated with socioeconomic inequities, addressing the nutritional status and food insecurity faced by TB patients are critical issues that need focused attention to devise optimal dietary care plans for this population. Advancements in genomic technologies and immunology can unravel the complexity of nutrient-TB disease interactions and improve the knowledge base for making informed decisions on the interventions needed. Well-designed studies combining a comprehensive assessment of lean body mass, macro, and micronutrient deficiencies, energy requirements, dietary habits, physical activity, cultural practices combined with genomic and epigenomic information are needed for improved assessment of nutritional needs and tailoring individualized nutrition plans for TB patients.

Original languageEnglish
Title of host publicationViral, Parasitic, Bacterial, and Fungal Infections
Subtitle of host publicationAntimicrobial, Host Defense, and Therapeutic Strategies
PublisherElsevier
Pages525-545
Number of pages21
ISBN (Electronic)9780323857307
ISBN (Print)9780323898003
DOIs
Publication statusPublished - 01-01-2022

All Science Journal Classification (ASJC) codes

  • General Medicine

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