Objective diagnosis of cervical cancer by tissue protein profile analysis

Ajeetkumar Patil*, Sujatha Bhat, Lavanya Rai, V. B. Kartha, Santhosh Chidangil

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Protein profiles of homogenized normal cervical tissue samples from hysterectomy subjects and cancerous cervical tissues from biopsy samples collected from patients with different stages of cervical cancer were recorded using High Performance Liquid Chromatography coupled with Laser Induced Fluorescence (HPLC-LIF). The Protein profiles were subjected to Principle Component Analysis to derive statistically significant parameters. Diagnosis of sample types were carried out by matching three parameters - scores of factors, squared residuals, and Mahalanobis Distance. ROC and Youden's Index curves for calibration standards were used for objective estimation of the optimum threshold for decision making and performance.

Original languageEnglish
Title of host publicationSolid State Physics - Proceedings of the 55th DAE Solid State Physics Symposium 2010
Pages226-227
Number of pages2
Volume1349
EditionPART A
DOIs
Publication statusPublished - 12-09-2011
Event55th DAE Solid State Physics Symposium 2010 - Manipal, India
Duration: 26-12-201030-12-2010

Publication series

NameAIP Conference Proceedings
NumberPART A
Volume1349
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference55th DAE Solid State Physics Symposium 2010
Country/TerritoryIndia
CityManipal
Period26-12-1030-12-10

All Science Journal Classification (ASJC) codes

  • General Physics and Astronomy

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