TY - JOUR
T1 - Optical Trap Combined with Raman Spectroscopy to Probe Red Blood Cell Behaviour in Certain Intravenous Fluids
AU - Lukose, Jijo
AU - Mohan, Ganesh
AU - Mithun, N.
AU - Shastry, Shamee
AU - Santhosh, C.
N1 - Funding Information:
Authors are thankful to DBT, DST-FIST, Govt. of. India and VGST, Govt. of Karnataka for providing the financial support for the fellows working in the project. Jijo Lukose also acknowledge Manipal Academy of Higher Education for the PostDoctoral fellowship. Authors also like to acknowledge Vittal Shenoy and the staffs in Blood Bank, Kasturba Medical College, Manipal for their support during this research work.
Funding Information:
Authors are thankful to DBT, DST-FIST, Govt. of. India and VGST, Govt. of Karnataka for providing the financial support for the fellows working in the project. Jijo Lukose also acknowledge Manipal Academy of Higher Education for the Post-Doctoral fellowship. Authors also like to acknowledge Vittal Shenoy and the staffs in Blood Bank, Kasturba Medical College, Manipal for their support during this research work.
Publisher Copyright:
© J-BPE.
PY - 2019
Y1 - 2019
N2 - Systematic studies on a live, individual human red blood cell without any chemical fixation can be realized with the aid of optical tweezers. In the present work, the behavior of human red blood cell in dextrose containing intravenous fluids and blood plasma were investigated and compared using a home-made near-IR Laser Tweezers Raman spectrometer. Significant spectral variations in Raman signatures exist between the RBCs in plasma and dextrose containing intravenous fluids, which mainly comprise of the hemoglobin oxygenation-deoxygenation transition as well as the heme aggregation markers.
AB - Systematic studies on a live, individual human red blood cell without any chemical fixation can be realized with the aid of optical tweezers. In the present work, the behavior of human red blood cell in dextrose containing intravenous fluids and blood plasma were investigated and compared using a home-made near-IR Laser Tweezers Raman spectrometer. Significant spectral variations in Raman signatures exist between the RBCs in plasma and dextrose containing intravenous fluids, which mainly comprise of the hemoglobin oxygenation-deoxygenation transition as well as the heme aggregation markers.
UR - https://www.scopus.com/pages/publications/85152160396
UR - https://www.scopus.com/pages/publications/85152160396#tab=citedBy
U2 - 10.18287/JBPE19.05.040302
DO - 10.18287/JBPE19.05.040302
M3 - Article
AN - SCOPUS:85152160396
SN - 2411-2844
VL - 5
JO - Journal of Biomedical Photonics and Engineering
JF - Journal of Biomedical Photonics and Engineering
IS - 4
M1 - 040302
ER -