Abstract
Nanomaterials have a broad spectrum of applications in biomedical fields. The carbon nanotubes (CNTs) are among the most versatile and well-characterised members of this group of materials. This review aims to discuss how to utilise CNTs as a diagnostic tool. Functionalisation with antibodies has gained significance in recent years among the various way of functionalisation of CNTs. Antibodies make their surface sensitive to surroundings for immuno-sensing. Surface passivation with other proteins is required to inhibit the non-specific binding of biomolecules on the hydrophobic carbon nanotube surface for ultrasensitive detection of biological species. CNT-based immuno-sensors provide excellent results with a promising sensitivity and reproducibility and, in combination with novel devices [such as a microfluidic electrochemical biosensor, nanoelectromechanical systems (NEMS), paper-based analytical devices (PADs), field effect transistors (FET)]. This combination offers an attractive analytical approach for the fast, low-cost, and accessible detection of trace prognostic biomarkers, microbial pathogens, environmental pollutants, and toxins.
Original language | English |
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Pages (from-to) | 217-238 |
Number of pages | 22 |
Journal | International Journal of Nanoparticles |
Volume | 11 |
Issue number | 3 |
DOIs | |
Publication status | Published - 01-01-2019 |
All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Condensed Matter Physics
- Mechanical Engineering