Oral cavity squamous cell carcinoma in a case of ichthyosis follicularis, alopecia, and photophobia syndrome with chronic myeloid leukemia on long-term hydroxyurea: A rare presentation

We report a case of a patient in his early 30s who presented with an ulceroproliferative growth over the left buccal mucosa; he was also on treatment for chronic myeloid leukemia in blast crisis on hydroxyurea and a known case of ichthyosis follicularis, alopecia, and photophobia syndrome. Although a working diagnosis of chloroma/hydroxyurea-induced erosive lichen planus was suspected, the histopathological examination of the lesion was suggestive of squamous cell carcinoma. He was subsequently planned for palliative radiotherapy.