Oral lesions containing amyloid-like material

Carla Isabelly Rodrigues-Fernandes, Cinthia Bardález López de Cáceres, Maria Sissa Pereira Sant'Ana, Ciro Dantas Soares, Maria Goretti Freire de Carvalho, Willie F.P. van Heerden, Liam Robinson, Raghu Radhakrishnan, Keith D. Hunter, Ricardo Santiago Gomez, Oslei Paes de Almeida, Pablo Agustin Vargas, Ömer Günhan, Ramiro Alejandro Tomasi, Faizan Alawi, Hélder Antônio Rebelo Pontes, Felipe Paiva Fonseca

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


During oral pathology daily practice, true amyloid may be identified in oral amyloidosis and several odontogenic tumors. However, histologic examination often reveals other oral and perioral diseases with similar eosinophilic, acellular, amorphous substances. These include extensive areas of collagenous sclerosis, fibrin deposition, elastic fiber degeneration, and dentinoid material, which may resemble amyloid under light microscopic examination. These materials are often termed “amyloid-like” due to their close histologic resemblance to true amyloid. The rarity of most of these conditions and their strong histologic similarity may hamper an accurate diagnosis. Definitive diagnosis of these lesions may require clinical correlation; laboratory evaluation; histochemical or immunohistochemical reactions; and, in some cases, genetic investigation. In this review, we describe the main clinicopathologic features of this group of diseases that may manifest in the oral and/or perioral regions and that have in common the presence of amyloid-like material deposition.

Original languageEnglish
Article number4557
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Publication statusPublished - 08-2021

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Dentistry (miscellaneous)
  • Radiology Nuclear Medicine and imaging


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