Oral manifestations of Chediak-Higashi syndrome: A systematic review

José Alcides Almeida de Arruda, Sebastião Silvério Sousa-Neto, Lucas Guimarães Abreu, Lauren Frenzel Schuch, Vinícius Gomes Souza, Thainara Vitória Lima Alves, Bárbara Martins-Andrade, Sameep S. Shetty, João Luiz Gomes Carneiro Monteiro, Elismauro Francisco Mendonça, Ricardo Alves Mesquita, Gerhilde Callou

Research output: Contribution to journalArticlepeer-review


Chediak-Higashi syndrome (CHS) is an autosomal recessive disorder characterized by leukocytes with giant secretory granules and a myriad of clinical features. However, it is unknown whether oral lesions are part of the syndrome or are refractory to systemic treatment. Herein, we integrated the available data published in the literature on the oral manifestations of individuals with CHS. Searches on PubMed, Web of Science, Embase, Scopus, and LILACS were conducted to identify studies published up to March/2022. The Joanna Briggs Institute tool was used for the critical appraisal of studies. Fourteen articles (21 cases) were detected. The mean age of individuals was 15.9±8.8 years. There was a slight predominance of males (52.4%). The major manifestation was periodontal disease (81%), although ulceration of the oral mucosa (14.3%), gingival/labial abscess (4.8%), and periodontal abscess (4.8%) were also reported. Oral rehabilitation including dental implants (9.5%) was performed after tooth losses due to the poor prognosis of periodontal therapy. CHS is usually diagnosed in an early stage due to its systemic manifestations such as classic oculocutaneous albinism, recurrent infections, and a propensity for bleeding. Oral health providers should be aware of the manifestations of individuals with CHS. Special care, including oral prophylaxis, is indispensable.

Original languageEnglish
Article number101356
Issue number1
Publication statusPublished - 01-2023

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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