TY - JOUR
T1 - Oral mucositis
T2 - Current knowledge and future directions
AU - Shetty, Sameep S.
AU - Maruthi, Meghana
AU - Dhara, Vasantha
AU - de Arruda, José Alcides Almeida
AU - Abreu, Lucas Guimarães
AU - Mesquita, Ricardo Alves
AU - Teixeira, Antonio Lucio
AU - Silva, Tarcília Aparecida
AU - Merchant, Yash
N1 - Funding Information:
This study was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Finance Code 001), Brazil. J.A.A.A. is the recipient of a fellowship. We also thank Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (#305493/2018-3; #435644/2018-1; #404710/2018-2; #310797/2019-5; #302157/2017-4). L.G.A., R.A.M., and T.A.S. are research fellows of CNPq. Mrs. E. Greene provided English editing of the manuscript.
Funding Information:
Source of Funding: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (#305493/2018-3; #435644/2018-1; #404710/2018-2; #310797/2019-5; #302157/2017-4).
Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2022/5
Y1 - 2022/5
N2 - Oral mucositis secondary to head and neck chemoradiation displays a complex molecular pathogenesis involving epithelial and microvascular injury, release of pro-inflammatory cytokines, and host-microbiome communications. These processes lead to oxidative stress and the release of reactive oxygen species that stifle the structural integrity of the oral mucosa, with emergence of erosions and ulcers. The consequences are malnutrition, psychological/psychiatric symptoms, poor quality of life, and occurrence of opportunistic infections. The latter pose a major challenge due to the risk of interruption of anti-neoplastic therapy, tumour recurrence and, ultimately, death. This article aims to present the clinical characteristics, molecular pathogenesis, and an overview of the predisposing factors and current management of oral mucositis. It is anticipated that the future direction of the management of oral mucositis will focus on evidence-based prehabilitation and pre- and per-chemoradiation therapy monitoring.
AB - Oral mucositis secondary to head and neck chemoradiation displays a complex molecular pathogenesis involving epithelial and microvascular injury, release of pro-inflammatory cytokines, and host-microbiome communications. These processes lead to oxidative stress and the release of reactive oxygen species that stifle the structural integrity of the oral mucosa, with emergence of erosions and ulcers. The consequences are malnutrition, psychological/psychiatric symptoms, poor quality of life, and occurrence of opportunistic infections. The latter pose a major challenge due to the risk of interruption of anti-neoplastic therapy, tumour recurrence and, ultimately, death. This article aims to present the clinical characteristics, molecular pathogenesis, and an overview of the predisposing factors and current management of oral mucositis. It is anticipated that the future direction of the management of oral mucositis will focus on evidence-based prehabilitation and pre- and per-chemoradiation therapy monitoring.
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U2 - 10.1016/j.disamonth.2021.101300
DO - 10.1016/j.disamonth.2021.101300
M3 - Article
AN - SCOPUS:85118693572
SN - 0011-5029
VL - 68
JO - Disease-a-Month
JF - Disease-a-Month
IS - 5
M1 - 101300
ER -
