TY - JOUR
T1 - Oral Squamous Cell Carcinoma Frequency in Young Patients from Referral Centers Around the World
AU - Ferreira e Costa, Rafael
AU - Leão, Marina Luiza Baião
AU - Sant’Ana, Maria Sissa Pereira
AU - Mesquita, Ricardo Alves
AU - Gomez, Ricardo Santiago
AU - Santos-Silva, Alan Roger
AU - Khurram, Syed Ali
AU - Tailor, Artysha
AU - Schouwstra, Ciska Mari
AU - Robinson, Liam
AU - van Heerden, Willie F.P.
AU - Tomasi, Ramiro Alejandro
AU - Gorrino, Romina
AU - de Prato, Ruth Salomé Ferreyra
AU - Taylor, Adalberto Mosqueda
AU - Urizar, José Manuel Aguirre
AU - de Mendoza, Irene Lafuente Ibañez
AU - Radhakrisnan, Raghu
AU - Chandrashekar, Chetana
AU - Choi, Siu Wai
AU - Thomson, Peter
AU - Pontes, Hélder Antônio Rebelo
AU - Fonseca, Felipe Paiva
N1 - Funding Information:
This study was supported by the Minas Gerais State Research Foundation (FAPEMIG), the Coordination for the Improvement of Higher Education Personnel (CAPES) (Financial code 001) and the National Council for Scientific and Technological Development (CNPq) (Brazil).
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022/9
Y1 - 2022/9
N2 - Oral squamous cell carcinoma (OSCC) commonly affects older patients; however, several studies have documented an increase in its incidence among younger patients. Therefore, it is important to investigate if this trend is also found in different geographic regions. The pathology files of diagnostic and therapeutic institutions from different parts of the globe were searched for OSCC cases diagnosed from 1998 to 2018. Data regarding the sex, age, and tumor location of all cases, as well as the histologic grade and history of exposure to risk habits of cases diagnosed as OSCC in young patients (≤ 40 years of age) were obtained. The Chi-square test was used to determine any increasing trend. A total of 10,727 OSCC cases were identified, of which 626 cases affected young patients (5.8%). Manipal institution (India) showed the highest number of young patients (13.2%). Males were the most affected in both age groups, with the tongue and floor of the mouth being the most affected subsites. OSCC in young individuals were usually graded as well or moderately differentiated. Only 0.9% of the cases occurred in young patients without a reported risk habit. There was no increasing trend in the institutions and the period investigated (p > 0.05), but a decreasing trend was observed in Hong Kong and the sample as a whole (p < 0.001). In conclusion there was no increase of OSCC in young patients in the institutions investigated and young white females not exposed to any known risk factor represented a rare group of patients affected by OSCC.
AB - Oral squamous cell carcinoma (OSCC) commonly affects older patients; however, several studies have documented an increase in its incidence among younger patients. Therefore, it is important to investigate if this trend is also found in different geographic regions. The pathology files of diagnostic and therapeutic institutions from different parts of the globe were searched for OSCC cases diagnosed from 1998 to 2018. Data regarding the sex, age, and tumor location of all cases, as well as the histologic grade and history of exposure to risk habits of cases diagnosed as OSCC in young patients (≤ 40 years of age) were obtained. The Chi-square test was used to determine any increasing trend. A total of 10,727 OSCC cases were identified, of which 626 cases affected young patients (5.8%). Manipal institution (India) showed the highest number of young patients (13.2%). Males were the most affected in both age groups, with the tongue and floor of the mouth being the most affected subsites. OSCC in young individuals were usually graded as well or moderately differentiated. Only 0.9% of the cases occurred in young patients without a reported risk habit. There was no increasing trend in the institutions and the period investigated (p > 0.05), but a decreasing trend was observed in Hong Kong and the sample as a whole (p < 0.001). In conclusion there was no increase of OSCC in young patients in the institutions investigated and young white females not exposed to any known risk factor represented a rare group of patients affected by OSCC.
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U2 - 10.1007/s12105-022-01441-w
DO - 10.1007/s12105-022-01441-w
M3 - Article
C2 - 35316511
AN - SCOPUS:85126840192
SN - 1936-055X
VL - 16
SP - 755
EP - 762
JO - Head and Neck Pathology
JF - Head and Neck Pathology
IS - 3
ER -