TY - JOUR
T1 - Organophosphate pesticide-induced toxicity through DNA damage and DNA repair mechanisms
AU - Prathiksha, Joyline
AU - Narasimhamurthy, Rekha K.
AU - Dsouza, Herman Sunil
AU - Mumbrekar, Kamalesh D.
N1 - Funding Information:
This work was supported by The Science and Engineering Research Board [Grant No: ECR/2017/001239/LS].
Funding Information:
The authors would like to thank the Director, Manipal School of Life Sciences and Manipal Academy of Higher Education (MAHE), for support and infrastructure facilities. Rekha would like to thank MAHE, Manipal, for the Dr. T.M.A Pai fellowship and KSTePS, Govt of Karnataka, for the scholarship.
Funding Information:
The authors would like to thank the Director, Manipal School of Life Sciences and Manipal Academy of Higher Education (MAHE), for support and infrastructure facilities. Rekha would like to thank MAHE, Manipal, for the Dr. T.M.A Pai fellowship and KSTePS, Govt of Karnataka, for the scholarship.
Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Nature B.V.
PY - 2023/6
Y1 - 2023/6
N2 - Organophosphate pesticides (OPs) are widely used in agriculture, healthcare, and other industries due to their ability to kill pests. However, OPs can also have genotoxic effects on humans who are exposed to them. This review summarizes the research on DNA damage caused by OPs, the mechanisms behind this damage, and the resulting cellular effects. Even at low doses, OPs have been shown to damage DNA and cause cellular dysfunction. Common phenomena seen in cells that are exposed to OPs include the formation of DNA adducts and lesions, single-strand and double-strand DNA breaks, and DNA and protein inter and intra-cross-links. The present review will aid in comprehending the extent of genetic damage and the impact on DNA repair pathways caused by acute or chronic exposure to OPs. Additionally, understanding the mechanisms of the effects of OPs will aid in correlating them with various diseases, including cancer, Alzheimer’s, and Parkinson’s disease. Overall, knowledge of the potential adverse effects of different OPs will help in monitoring the health complications they may cause.
AB - Organophosphate pesticides (OPs) are widely used in agriculture, healthcare, and other industries due to their ability to kill pests. However, OPs can also have genotoxic effects on humans who are exposed to them. This review summarizes the research on DNA damage caused by OPs, the mechanisms behind this damage, and the resulting cellular effects. Even at low doses, OPs have been shown to damage DNA and cause cellular dysfunction. Common phenomena seen in cells that are exposed to OPs include the formation of DNA adducts and lesions, single-strand and double-strand DNA breaks, and DNA and protein inter and intra-cross-links. The present review will aid in comprehending the extent of genetic damage and the impact on DNA repair pathways caused by acute or chronic exposure to OPs. Additionally, understanding the mechanisms of the effects of OPs will aid in correlating them with various diseases, including cancer, Alzheimer’s, and Parkinson’s disease. Overall, knowledge of the potential adverse effects of different OPs will help in monitoring the health complications they may cause.
UR - https://www.scopus.com/pages/publications/85158137696
UR - https://www.scopus.com/pages/publications/85158137696#tab=citedBy
U2 - 10.1007/s11033-023-08424-2
DO - 10.1007/s11033-023-08424-2
M3 - Review article
AN - SCOPUS:85158137696
SN - 0301-4851
VL - 50
SP - 5465
EP - 5479
JO - Molecular Biology Reports
JF - Molecular Biology Reports
IS - 6
ER -
SDG 3 Good Health and Well-being