Orthopedic manifestation as the presenting symptom of acute lymphoblastic leukemia

Introduction: The diagnosis of Acute lymphoblastic leukemia (ALL) is delayed due to vague presentation and normal hematological investigations. Objective: The objectives were to identify the frequency of ALL cases presented to the orthopedic department and with normal hematological investigations. Material and methods: 250 consecutive ALL cases were retrospectively evaluated to identify cases with musculoskeletal manifestations, and laboratory investigations. Results: Twenty-two patients (4- vertebral compression fractures, 12- joint pain, 6- bone pain), presented primarily to the orthopedic department. Six patients had a normal peripheral smear. Conclusion: The primary physician should maintain a high index of suspicion despite a normal peripheral smear.