TY - JOUR
T1 - Over 60 years of age as an independent prognostic factor of in-hospital mortality among COVID-19 patients
T2 - a cohort study in an Iranian high-incidence area
AU - Navayi, M.
AU - Fanoodi, A.
AU - Salmani, F.
AU - Abedi, F.
AU - Shetty, S.
AU - Riahi, S. M.
N1 - Funding Information:
The authors wish to thank the Deputy of Research and Technology of Birjand University of Medical Sciences for support (grant number: 456203).
Publisher Copyright:
© 2021 The Royal Society for Public Health
PY - 2021/11
Y1 - 2021/11
N2 - Objectives: COVID-19 continues to cause devastation throughout the world. Various factors influence the perioperative course and prognosis of COVID-19. This study aims to collate the independent prognostic factors among hospitalised COVID-19 patients in east Iran. Study design: In this cohort study, all patients with a confirmed diagnosis of COVID-19 between 19 February 2020 and 1 August 2020 who were admitted to nine public hospitals of South Khorasan province, Iran, were enrolled. Methods: Univariate analysis (chi-square [χ2], and Mann–Whitney U test) and multiple logistic regression were performed. Results: This study included 1290 participants; 676 patients (52.4%) were male. A total of 1189 (92.2%) recovered, and 101 (7.8%) died. The results show that in-hospital mortality increases with advanced age (the optimal cut-off point = 62 years). The following three variables were shown to have the most significant role in in-hospital mortality: age >60 years (odds ratio [OR] = 8.01, 95% confidence interval [CI] 4.8–13.35), shortness of breath (OR = 2.65, 95% CI: 1.4–69.17) and atypical radiological manifestations in a chest X-ray on admission (OR = 2.16, 95% CI: 1.3–28.64). In the univariate analysis, associated comorbidities, such as cardiovascular diseases, influenced the in-hospital mortality rate, while the same could not be replicated in the multiple variable analysis. Conclusions: This study revealed the potential predictors of COVID-19 and highlighted the need to be cautious with advanced age and heightened clinical symptoms at the time of admission.
AB - Objectives: COVID-19 continues to cause devastation throughout the world. Various factors influence the perioperative course and prognosis of COVID-19. This study aims to collate the independent prognostic factors among hospitalised COVID-19 patients in east Iran. Study design: In this cohort study, all patients with a confirmed diagnosis of COVID-19 between 19 February 2020 and 1 August 2020 who were admitted to nine public hospitals of South Khorasan province, Iran, were enrolled. Methods: Univariate analysis (chi-square [χ2], and Mann–Whitney U test) and multiple logistic regression were performed. Results: This study included 1290 participants; 676 patients (52.4%) were male. A total of 1189 (92.2%) recovered, and 101 (7.8%) died. The results show that in-hospital mortality increases with advanced age (the optimal cut-off point = 62 years). The following three variables were shown to have the most significant role in in-hospital mortality: age >60 years (odds ratio [OR] = 8.01, 95% confidence interval [CI] 4.8–13.35), shortness of breath (OR = 2.65, 95% CI: 1.4–69.17) and atypical radiological manifestations in a chest X-ray on admission (OR = 2.16, 95% CI: 1.3–28.64). In the univariate analysis, associated comorbidities, such as cardiovascular diseases, influenced the in-hospital mortality rate, while the same could not be replicated in the multiple variable analysis. Conclusions: This study revealed the potential predictors of COVID-19 and highlighted the need to be cautious with advanced age and heightened clinical symptoms at the time of admission.
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U2 - 10.1016/j.puhe.2021.09.007
DO - 10.1016/j.puhe.2021.09.007
M3 - Article
AN - SCOPUS:85117094437
SN - 0033-3506
VL - 200
SP - 33
EP - 38
JO - Public Health
JF - Public Health
ER -
