Oxazolidine-2-thiones: A molecular modeling study

Neha Gandhi; Brijesh K. Srivastava; Vidya B. Lohray; Braj B. Lohray

doi:10.1016/j.tetlet.2004.06.090

Oxazolidine-2-thiones: A molecular modeling study

Neha Gandhi
, Brijesh K. Srivastava
, Vidya B. Lohray
, Braj B. Lohray

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Two oxazolidine-2-thiones, thio-analogs of linezolid, were synthesized and their antibacterial properties evaluated. Unlike oxazolidinones, the thio-analogs did not inhibit the growth of Gram positive bacteria. A molecular modeling study has been carried out to aid understanding of this unexpected finding. Two oxazolidine-2-thiones, thio-analogs of linezolid, were synthesized and their antibacterial properties evaluated. Unlike oxazolidinones, the thio-analogs did not inhibit the growth of Gram positive bacteria. A molecular modeling study has been carried out to aid understanding of this unexpected finding.

Original language	English
Pages (from-to)	6269-6272
Number of pages	4
Journal	Tetrahedron Letters
Volume	45
Issue number	33
DOIs	https://doi.org/10.1016/j.tetlet.2004.06.090
Publication status	Published - 09-08-2004

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2004.06.090

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title = "Oxazolidine-2-thiones: A molecular modeling study",

abstract = "Two oxazolidine-2-thiones, thio-analogs of linezolid, were synthesized and their antibacterial properties evaluated. Unlike oxazolidinones, the thio-analogs did not inhibit the growth of Gram positive bacteria. A molecular modeling study has been carried out to aid understanding of this unexpected finding. Two oxazolidine-2-thiones, thio-analogs of linezolid, were synthesized and their antibacterial properties evaluated. Unlike oxazolidinones, the thio-analogs did not inhibit the growth of Gram positive bacteria. A molecular modeling study has been carried out to aid understanding of this unexpected finding.",

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doi = "10.1016/j.tetlet.2004.06.090",

language = "English",

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journal = "Tetrahedron Letters",

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T2 - A molecular modeling study

AU - Gandhi, Neha

AU - Srivastava, Brijesh K.

AU - Lohray, Vidya B.

AU - Lohray, Braj B.

PY - 2004/8/9

Y1 - 2004/8/9

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AB - Two oxazolidine-2-thiones, thio-analogs of linezolid, were synthesized and their antibacterial properties evaluated. Unlike oxazolidinones, the thio-analogs did not inhibit the growth of Gram positive bacteria. A molecular modeling study has been carried out to aid understanding of this unexpected finding. Two oxazolidine-2-thiones, thio-analogs of linezolid, were synthesized and their antibacterial properties evaluated. Unlike oxazolidinones, the thio-analogs did not inhibit the growth of Gram positive bacteria. A molecular modeling study has been carried out to aid understanding of this unexpected finding.

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UR - https://www.scopus.com/pages/publications/3242758937#tab=citedBy

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DO - 10.1016/j.tetlet.2004.06.090

M3 - Article

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SN - 0040-4039

VL - 45

SP - 6269

EP - 6272

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 33

ER -

Oxazolidine-2-thiones: A molecular modeling study

Abstract

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