Paget's disease of bone: An entity still exists in India

Kripa Elizabeth Cherian; Nitin Kapoor; Sahana Shetty; Felix K. Jebasingh; Hesarghatta Shyamasunder Asha; Julie Hephzibah; Anne Jennifer Prabhu; Simon Rajaratnam; Nihal Thomas; Thomas Vizhalil Paul

doi:10.4103/ijem.IJEM-19-18

Paget's disease of bone: An entity still exists in India

Kripa Elizabeth Cherian
, Nitin Kapoor
, Sahana Shetty
, Felix K. Jebasingh
, Hesarghatta Shyamasunder Asha
, Julie Hephzibah
, Anne Jennifer Prabhu
, Simon Rajaratnam
, Nihal Thomas
, Thomas Vizhalil Paul^*

^*Corresponding author for this work

Department of Endocrinology, Kasturba Medical College, Manipal

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Background: Paget's disease of bone (PDB) is uncommonly reported from India. We attempted to study the clinical and imaging features and management of participants who presented with PDB. Materials and Methods: In this retrospective study, clinical and imaging profile, biochemistry, and treatment outcomes of participants with PDB (n = 48) were obtained. Results: The mean age was 60 ± 11.3 years and 35% were women. Twenty percent were asymptomatic. Many (87%) had polyostotic involvement. Sixty percent (n = 29) underwent treatment with zoledronic acid and rest with oral bisphosphonates, and all achieved remission. Conclusion: Most of the pagetic participants had polyostotic disease and one-fifth were asymptomatic. All participants had disease remission following treatment.

Original language	English
Pages (from-to)	368-372
Number of pages	5
Journal	Indian Journal of Endocrinology and Metabolism
Volume	22
Issue number	3
DOIs	https://doi.org/10.4103/ijem.IJEM-19-18
Publication status	Published - 01-05-2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.4103/ijem.IJEM-19-18

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title = "Paget's disease of bone: An entity still exists in India",

abstract = "Background: Paget's disease of bone (PDB) is uncommonly reported from India. We attempted to study the clinical and imaging features and management of participants who presented with PDB. Materials and Methods: In this retrospective study, clinical and imaging profile, biochemistry, and treatment outcomes of participants with PDB (n = 48) were obtained. Results: The mean age was 60 ± 11.3 years and 35\% were women. Twenty percent were asymptomatic. Many (87\%) had polyostotic involvement. Sixty percent (n = 29) underwent treatment with zoledronic acid and rest with oral bisphosphonates, and all achieved remission. Conclusion: Most of the pagetic participants had polyostotic disease and one-fifth were asymptomatic. All participants had disease remission following treatment.",

author = "Cherian, \{Kripa Elizabeth\} and Nitin Kapoor and Sahana Shetty and Jebasingh, \{Felix K.\} and Asha, \{Hesarghatta Shyamasunder\} and Julie Hephzibah and Prabhu, \{Anne Jennifer\} and Simon Rajaratnam and Nihal Thomas and Paul, \{Thomas Vizhalil\}",

note = "Publisher Copyright: {\textcopyright} 2018 Indian Journal of Endocrinology and Metabolism | Published by Wolters Kluwer - Medknow.",

year = "2018",

month = may,

day = "1",

doi = "10.4103/ijem.IJEM-19-18",

language = "English",

volume = "22",

pages = "368--372",

journal = "Indian Journal of Endocrinology and Metabolism",

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publisher = "Wolters Kluwer Medknow Publications",

number = "3",

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TY - JOUR

T1 - Paget's disease of bone

T2 - An entity still exists in India

AU - Cherian, Kripa Elizabeth

AU - Kapoor, Nitin

AU - Shetty, Sahana

AU - Jebasingh, Felix K.

AU - Asha, Hesarghatta Shyamasunder

AU - Hephzibah, Julie

AU - Prabhu, Anne Jennifer

AU - Rajaratnam, Simon

AU - Thomas, Nihal

AU - Paul, Thomas Vizhalil

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Background: Paget's disease of bone (PDB) is uncommonly reported from India. We attempted to study the clinical and imaging features and management of participants who presented with PDB. Materials and Methods: In this retrospective study, clinical and imaging profile, biochemistry, and treatment outcomes of participants with PDB (n = 48) were obtained. Results: The mean age was 60 ± 11.3 years and 35% were women. Twenty percent were asymptomatic. Many (87%) had polyostotic involvement. Sixty percent (n = 29) underwent treatment with zoledronic acid and rest with oral bisphosphonates, and all achieved remission. Conclusion: Most of the pagetic participants had polyostotic disease and one-fifth were asymptomatic. All participants had disease remission following treatment.

AB - Background: Paget's disease of bone (PDB) is uncommonly reported from India. We attempted to study the clinical and imaging features and management of participants who presented with PDB. Materials and Methods: In this retrospective study, clinical and imaging profile, biochemistry, and treatment outcomes of participants with PDB (n = 48) were obtained. Results: The mean age was 60 ± 11.3 years and 35% were women. Twenty percent were asymptomatic. Many (87%) had polyostotic involvement. Sixty percent (n = 29) underwent treatment with zoledronic acid and rest with oral bisphosphonates, and all achieved remission. Conclusion: Most of the pagetic participants had polyostotic disease and one-fifth were asymptomatic. All participants had disease remission following treatment.

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UR - https://www.scopus.com/pages/publications/85050375051#tab=citedBy

U2 - 10.4103/ijem.IJEM-19-18

DO - 10.4103/ijem.IJEM-19-18

M3 - Article

AN - SCOPUS:85050375051

SN - 2230-8210

VL - 22

SP - 368

EP - 372

JO - Indian Journal of Endocrinology and Metabolism

JF - Indian Journal of Endocrinology and Metabolism

IS - 3

ER -

Paget's disease of bone: An entity still exists in India

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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