Pathogenic arsenal of Pseudomonas aeruginosa: an update on virulence factors

Vimal V. Veetilvalappil, Atulya Manuel, Jesil M. Aranjani, Roshan Tawale, Ananthamurthy Koteshwara

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)


The emergence of Pseudomonas aeruginosa as a potential threat in persistent infections can be attributed to the plethora of virulence factors expressed by it. This review discusses the various virulence factors that help this pathogen to establish an infection and regulatory systems controlling these virulence factors. Cell-associated virulence factors such as flagella, type IV pili and non-pilus adhesins have been reviewed. Extracellular virulence factors have also been explained. Quorum-sensing systems present in P. aeruginosa play a cardinal role in regulating the expression of virulence factors. The identification of novel virulence factors in hypervirulent strains indicate that the expression of virulence is dynamic and constantly evolving. An understanding of this is critical for the better clinical management of infections.

Original languageEnglish
Pages (from-to)465-481
Number of pages17
JournalFuture Microbiology
Issue number6
Publication statusPublished - 04-2022

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)


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