Pharmacognostical standardisation and cytotoxicity screening of Bridelia retusa spreng

Seena Kanniparambil Xavier; Praveen Kallamvalliillam Sankaran; Devkar Raviraj Ananad; Chandrasekhara Shastry Shreedhara; Manganahally Manjunath Setty

doi:10.1166/asl.2017.8500

Pharmacognostical standardisation and cytotoxicity screening of Bridelia retusa spreng

Seena Kanniparambil Xavier, Praveen Kallamvalliillam Sankaran, Devkar Raviraj Ananad, Chandrasekhara Shastry Shreedhara, Manganahally Manjunath Setty

Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

Abstract

Bridelia retusa is an indigenous medicinal plants belonging to family Euphorbiaceae and are used in the treatment of various disorders such as inflammation, kidney stones, urinary disorders, diarrhoea and dysentery. The stem bark of Bridelia retusa was subjected for macro and microscopical analysis, various physico chemical standardisation parameters and phytochemical studies according to Indian Pharmacopoeia. Total phenolic and flavonoid content were estimated using standard procedures. Cytotoxicity screening of methanol extract of Bridelia retusa was performed in Vero cells by sulforhodamine assay. The present study provides standardisation parameters for Bridelia retusa which will aid in the proper identification and authentication of the plant. Further, results of cytotoxicity screening revealed that plant exhibits no toxicity even at higher concentration and IC₅₀ was found to be 430.6 μg/ml.

Original language	English
Pages (from-to)	1773-1776
Number of pages	4
Journal	Advanced Science Letters
Volume	23
Issue number	3
DOIs	https://doi.org/10.1166/asl.2017.8500
Publication status	Published - 01-03-2017

All Science Journal Classification (ASJC) codes

Health(social science)
Computer Science(all)
Education
Mathematics(all)
Environmental Science(all)
Engineering(all)
Energy(all)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1166/asl.2017.8500

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abstract = "Bridelia retusa is an indigenous medicinal plants belonging to family Euphorbiaceae and are used in the treatment of various disorders such as inflammation, kidney stones, urinary disorders, diarrhoea and dysentery. The stem bark of Bridelia retusa was subjected for macro and microscopical analysis, various physico chemical standardisation parameters and phytochemical studies according to Indian Pharmacopoeia. Total phenolic and flavonoid content were estimated using standard procedures. Cytotoxicity screening of methanol extract of Bridelia retusa was performed in Vero cells by sulforhodamine assay. The present study provides standardisation parameters for Bridelia retusa which will aid in the proper identification and authentication of the plant. Further, results of cytotoxicity screening revealed that plant exhibits no toxicity even at higher concentration and IC50 was found to be 430.6 μg/ml.",

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AU - Xavier, Seena Kanniparambil

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AU - Ananad, Devkar Raviraj

AU - Shreedhara, Chandrasekhara Shastry

AU - Setty, Manganahally Manjunath

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Pharmacognostical standardisation and cytotoxicity screening of Bridelia retusa spreng

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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