Pharmacokinetic evaluation of a developed nicotine transdermal system

Shaila Lewis; G. Subramanian; S. Pandey; N. Udupa

Pharmacokinetic evaluation of a developed nicotine transdermal system

Shaila Lewis, G. Subramanian, S. Pandey, N. Udupa

Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal
Department of Pharmacy Management, Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The plasma concentration time profiles for nicotine were characterized after a single application of nicotine transdermal system to the upper fore arm of healthy smokers. A 12 cm² system was applied for 24 h. Blood samples were withdrawn at predetermined time intervals. Plasma nicotine concentrations rose rapidly and achieved a mean C_maxvalue of 14.5 ng/ml.The half life was estimated as 4.78 h and AUC_(0-24)181.0 ng.h/ ml. The nicotine transdermal system was well tolerated. The results indicate that the system has potential usefulness in smoking cessation. The pharmacokinetic profiles of marketed patch system was compared with the developed system. Significant difference was observed in the pharmacokinetic parameters.

Original language	English
Pages (from-to)	309-312
Number of pages	4
Journal	Indian Journal of Pharmaceutical Sciences
Volume	69
Issue number	2
Publication status	Published - 03-2007

All Science Journal Classification (ASJC) codes

Pharmaceutical Science

Cite this

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abstract = "The plasma concentration time profiles for nicotine were characterized after a single application of nicotine transdermal system to the upper fore arm of healthy smokers. A 12 cm2 system was applied for 24 h. Blood samples were withdrawn at predetermined time intervals. Plasma nicotine concentrations rose rapidly and achieved a mean Cmaxvalue of 14.5 ng/ml.The half life was estimated as 4.78 h and AUC(0-24)181.0 ng.h/ ml. The nicotine transdermal system was well tolerated. The results indicate that the system has potential usefulness in smoking cessation. The pharmacokinetic profiles of marketed patch system was compared with the developed system. Significant difference was observed in the pharmacokinetic parameters.",

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N2 - The plasma concentration time profiles for nicotine were characterized after a single application of nicotine transdermal system to the upper fore arm of healthy smokers. A 12 cm2 system was applied for 24 h. Blood samples were withdrawn at predetermined time intervals. Plasma nicotine concentrations rose rapidly and achieved a mean Cmaxvalue of 14.5 ng/ml.The half life was estimated as 4.78 h and AUC(0-24)181.0 ng.h/ ml. The nicotine transdermal system was well tolerated. The results indicate that the system has potential usefulness in smoking cessation. The pharmacokinetic profiles of marketed patch system was compared with the developed system. Significant difference was observed in the pharmacokinetic parameters.

AB - The plasma concentration time profiles for nicotine were characterized after a single application of nicotine transdermal system to the upper fore arm of healthy smokers. A 12 cm2 system was applied for 24 h. Blood samples were withdrawn at predetermined time intervals. Plasma nicotine concentrations rose rapidly and achieved a mean Cmaxvalue of 14.5 ng/ml.The half life was estimated as 4.78 h and AUC(0-24)181.0 ng.h/ ml. The nicotine transdermal system was well tolerated. The results indicate that the system has potential usefulness in smoking cessation. The pharmacokinetic profiles of marketed patch system was compared with the developed system. Significant difference was observed in the pharmacokinetic parameters.

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Pharmacokinetic evaluation of a developed nicotine transdermal system

Abstract

All Science Journal Classification (ASJC) codes

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