Pharmacokinetic evaluation of surfactant vesicle-entrapped methotrexate in tumor-bearing mice

K. S. Chandraprakash; N. Udupa; P. Umadevi; G. K. Pillai

doi:10.1016/0378-5173(90)90056-A

Pharmacokinetic evaluation of surfactant vesicle-entrapped methotrexate in tumor-bearing mice

K. S. Chandraprakash
, N. Udupa
, P. Umadevi
, G. K. Pillai^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

Methotrexate was encapsulated in niosomes. The entrapment efficiency increased with increase in lipophilicity of surfactant. Unilamellar vesicles prepared with span 60 showed maximum entrapment and its pharmacokinetics in mice transplanted with S-180 tumor was markedly different in comparison to unentrapped methotrexate.

Original language	English
Pages (from-to)	R1-R4
Journal	International Journal of Pharmaceutics
Volume	61
Issue number	1-2
DOIs	https://doi.org/10.1016/0378-5173(90)90056-A
Publication status	Published - 11-06-1990

All Science Journal Classification (ASJC) codes

Pharmaceutical Science

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10.1016/0378-5173(90)90056-A

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title = "Pharmacokinetic evaluation of surfactant vesicle-entrapped methotrexate in tumor-bearing mice",

abstract = "Methotrexate was encapsulated in niosomes. The entrapment efficiency increased with increase in lipophilicity of surfactant. Unilamellar vesicles prepared with span 60 showed maximum entrapment and its pharmacokinetics in mice transplanted with S-180 tumor was markedly different in comparison to unentrapped methotrexate.",

author = "Chandraprakash, \{K. S.\} and N. Udupa and P. Umadevi and Pillai, \{G. K.\}",

year = "1990",

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T1 - Pharmacokinetic evaluation of surfactant vesicle-entrapped methotrexate in tumor-bearing mice

AU - Chandraprakash, K. S.

AU - Udupa, N.

AU - Umadevi, P.

AU - Pillai, G. K.

PY - 1990/6/11

Y1 - 1990/6/11

N2 - Methotrexate was encapsulated in niosomes. The entrapment efficiency increased with increase in lipophilicity of surfactant. Unilamellar vesicles prepared with span 60 showed maximum entrapment and its pharmacokinetics in mice transplanted with S-180 tumor was markedly different in comparison to unentrapped methotrexate.

AB - Methotrexate was encapsulated in niosomes. The entrapment efficiency increased with increase in lipophilicity of surfactant. Unilamellar vesicles prepared with span 60 showed maximum entrapment and its pharmacokinetics in mice transplanted with S-180 tumor was markedly different in comparison to unentrapped methotrexate.

UR - https://www.scopus.com/pages/publications/0025314159

UR - https://www.scopus.com/pages/publications/0025314159#tab=citedBy

U2 - 10.1016/0378-5173(90)90056-A

DO - 10.1016/0378-5173(90)90056-A

M3 - Article

AN - SCOPUS:0025314159

SN - 0378-5173

VL - 61

SP - R1-R4

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-2

ER -

Pharmacokinetic evaluation of surfactant vesicle-entrapped methotrexate in tumor-bearing mice

Abstract

All Science Journal Classification (ASJC) codes

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