TY - JOUR
T1 - Pharmacological Activities of Psoralidin
T2 - A Comprehensive Review of the Molecular Mechanisms of Action
AU - Sharifi-Rad, Javad
AU - Kamiloglu, Senem
AU - Yeskaliyeva, Balakyz
AU - Beyatli, Ahmet
AU - Alfred, Mary Angelia
AU - Salehi, Bahare
AU - Calina, Daniela
AU - Docea, Anca Oana
AU - Imran, Muhammad
AU - Anil Kumar, Nanjangud Venaktesh
AU - Romero-Román, Maria Eugenia
AU - Maroyi, Alfred
AU - Martorell, Miquel
N1 - Funding Information:
This work was supported by CONICYT PIA/APOYO CCTE AFB170007.
Publisher Copyright:
© Copyright © 2020 Sharifi-Rad, Kamiloglu, Yeskaliyeva, Beyatli, Alfred, Salehi, Calina, Docea, Imran, Anil Kumar, Eugenia Romero-Román, Maroyi and Martorell.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/10/22
Y1 - 2020/10/22
N2 - Analysis of the most relevant studies on the pharmacological properties and molecular mechanisms of psoralidin, a bioactive compound from the seeds of Cullen corylifolium (L.) Medik. confirmed its complex therapeutic potential. In the last years, the interest of the scientific community regarding psoralidin increased, especially after the discovery of its benefits in estrogen-related diseases and as a chemopreventive agent. Growing preclinical pieces of evidence indicate that psoralidin has anticancer, antiosteoporotic, anti-inflammatory, anti-vitiligo, antibacterial, antiviral, and antidepressant-like effects. Here, we provide a comprehensive and critical review of psoralidin on its bioavailability, pharmacological activities with focus on molecular mechanisms and cell signaling pathways. In this review, we conducted literature research on the PubMed database using the following keywords: “Psoralidin” or “therapeutic effects” or “biological activity” or “Cullen corylifolium” in order to identify relevant studies regarding PSO bioavailability and mechanisms of therapeutic effects in different diseases based on preclinical, experimental studies. In the light of psoralidin beneficial actions for human health, this paper gathers complete information on its pharmacotherapeutic effects and opens new natural therapeutic perspectives in chronic diseases.
AB - Analysis of the most relevant studies on the pharmacological properties and molecular mechanisms of psoralidin, a bioactive compound from the seeds of Cullen corylifolium (L.) Medik. confirmed its complex therapeutic potential. In the last years, the interest of the scientific community regarding psoralidin increased, especially after the discovery of its benefits in estrogen-related diseases and as a chemopreventive agent. Growing preclinical pieces of evidence indicate that psoralidin has anticancer, antiosteoporotic, anti-inflammatory, anti-vitiligo, antibacterial, antiviral, and antidepressant-like effects. Here, we provide a comprehensive and critical review of psoralidin on its bioavailability, pharmacological activities with focus on molecular mechanisms and cell signaling pathways. In this review, we conducted literature research on the PubMed database using the following keywords: “Psoralidin” or “therapeutic effects” or “biological activity” or “Cullen corylifolium” in order to identify relevant studies regarding PSO bioavailability and mechanisms of therapeutic effects in different diseases based on preclinical, experimental studies. In the light of psoralidin beneficial actions for human health, this paper gathers complete information on its pharmacotherapeutic effects and opens new natural therapeutic perspectives in chronic diseases.
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U2 - 10.3389/fphar.2020.571459
DO - 10.3389/fphar.2020.571459
M3 - Review article
AN - SCOPUS:85095576565
SN - 1663-9812
VL - 11
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
M1 - 571459
ER -