Physiological role of cholesterol in human body

M. Sonal Sekhar; B. Shrikar Reddy; Shilia Jacob Kurian; Mahadev Rao; Srujitha Marupuru

doi:10.1016/B978-0-12-816918-6.00021-4

Physiological role of cholesterol in human body

M. Sonal Sekhar, B. Shrikar Reddy, Shilia Jacob Kurian, Mahadev Rao, Srujitha Marupuru

Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal

Research output: Chapter in Book/Report/Conference proceeding › Chapter

11 Citations (Scopus)

Abstract

Cholesterol is a biomolecule present in almost all cells of the human body. Cholesterol has a bidirectional (both good and bad) role in the body. The chapter focuses on chemistry, biochemistry, pathology, and biological roles of cholesterol in human body. The chapter begins with historical aspects of the cholesterol, together with structure and its biosynthesis in vivo. This follows a comprehensive discussion on lipids and lipoproteins and their roles in cholesterol transport. There are sections, which focus on metabolism of lipoprotein; and different receptors as well as pathways involved in regulation of levels of cholesterol in the plasma as well as intracellular. Additionally, the chapter details physiology of cholesterol including distribution of sterols across human tissues and organs such as brain, retina, and its importance in embryonic development.

Original language	English
Title of host publication	Dietary Sugar, Salt and Fat in Human Health
Publisher	Elsevier
Pages	453-481
Number of pages	29
ISBN (Electronic)	9780128169186
ISBN (Print)	9780128169193
DOIs	https://doi.org/10.1016/B978-0-12-816918-6.00021-4
Publication status	Published - 01-01-2020

All Science Journal Classification (ASJC) codes

General Health Professions
General Medicine

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10.1016/B978-0-12-816918-6.00021-4

Cite this

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AU - Kurian, Shilia Jacob

AU - Rao, Mahadev

AU - Marupuru, Srujitha

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AB - Cholesterol is a biomolecule present in almost all cells of the human body. Cholesterol has a bidirectional (both good and bad) role in the body. The chapter focuses on chemistry, biochemistry, pathology, and biological roles of cholesterol in human body. The chapter begins with historical aspects of the cholesterol, together with structure and its biosynthesis in vivo. This follows a comprehensive discussion on lipids and lipoproteins and their roles in cholesterol transport. There are sections, which focus on metabolism of lipoprotein; and different receptors as well as pathways involved in regulation of levels of cholesterol in the plasma as well as intracellular. Additionally, the chapter details physiology of cholesterol including distribution of sterols across human tissues and organs such as brain, retina, and its importance in embryonic development.

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ER -

Physiological role of cholesterol in human body

Abstract

All Science Journal Classification (ASJC) codes

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