Phytochemical Constituents, Biological Activities, and Health-Promoting Effects of the Melissa officinalis

Javad Sharifi-Rad, Cristina Quispe, Jesús Herrera-Bravo, Muhammad Akram, Wafa Abbaass, Prabhakar Semwal, Sakshi Painuli, Dmitry Alekseevich Konovalov, Mary Angelia Alfred, Nanjangud Venkatesh Anil Kumar, Muhammad Imran, Muhammad Nadeem, Barbara Sawicka, Piotr Pszczółkowski, Bernadetta Bienia, Piotr Barbaś, Shafi Mahmud, Alessandra Durazzo, Massimo Lucarini, Antonello SantiniMiquel Martorell, Daniela Calina

Research output: Contribution to journalReview articlepeer-review

25 Citations (Scopus)


Medicinal plants are being used worldwide for centuries for their beneficial properties. Some of the most popular medicinal plants belong to the Melissa genus, and different health beneficial effects have already been identified for this genus. Among these species, in particular, the Melissa officinalis L. has been reported as having many biological activities, such as antioxidant, antimicrobial, antitumour, antiviral, antiallergic, anti-inflammatory, and also flatulence inhibiting effects. The beneficial properties of the Melissa officinalis, also known as “lemon balm herb”, can be related to the bioactive compounds such as terpenoids, alcohols, rosmarinic acid, and phenolic antioxidants which are present in the plant. In this updated review, the botanical, geographical, nutritional, phytochemical, and traditional medical aspects of M. officinalis have been considered as well as in vitro and in vivo and clinically proven therapeutic properties have been reviewed with a special focus on health-promoting effects and possible perspective nutraceutical applications. To evidence the relevance of this plant in the research and completely assess the context, a literature quantitative research analysis has been performed indicating the great interest towards this plant for its beneficial properties.

Original languageEnglish
Article number6584693
JournalOxidative Medicine and Cellular Longevity
Publication statusPublished - 2021

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Ageing
  • Cell Biology


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