TY - JOUR
T1 - Phytosynthesis of gold nanoparticles
T2 - Characterization, biocompatibility, and evaluation of its osteoinductive potential for application in implant dentistry
AU - Jadhav, Kiran
AU - HR, Rajeshwari
AU - Deshpande, Swapnil
AU - Jagwani, Satveer
AU - Dhamecha, Dinesh
AU - Jalalpure, Sunil
AU - Subburayan, Karthikeyan
AU - Baheti, Dwarkadas
N1 - Publisher Copyright:
© 2018
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Gold nanoparticles have been extensively used in diagnostics, biomedical imaging, and drug delivery owing to simple method of synthesis and versatile surface functionalization. Present investigation aims to evaluate the osteoinductive property of Salacia chinensis (SC) mediated gold nanoparticles (GNPs) for its application in implant dentistry. The formation of GNPs was assessed initially using the visual method and characterized analytically by using UV–visible spectroscopy, Zetasizer, X-RD, ICP-AES, AFM, and TEM. Green synthesized GNPs exhibited a remarkable stability in various blood components (0.2 M histidine, 0.2 M cysteine 2% bovine serum albumin, and 2% human serum albumin) and were found to be nontoxic when evaluated for their cytocompatibility and blood compatibility using periodontal fibroblasts and erythrocytes respectively. Exposure of GNPs to MG-63 cell lines displayed increased percent cell viability (138 ± 27.4) compared to the control group (96 ± 3.7) which confirms its osteoinductive potential. Herein, it can be concluded that the stable, biocompatible and eco-friendly GNPs can be used as an effective bone inductive agent during dental implant therapy.
AB - Gold nanoparticles have been extensively used in diagnostics, biomedical imaging, and drug delivery owing to simple method of synthesis and versatile surface functionalization. Present investigation aims to evaluate the osteoinductive property of Salacia chinensis (SC) mediated gold nanoparticles (GNPs) for its application in implant dentistry. The formation of GNPs was assessed initially using the visual method and characterized analytically by using UV–visible spectroscopy, Zetasizer, X-RD, ICP-AES, AFM, and TEM. Green synthesized GNPs exhibited a remarkable stability in various blood components (0.2 M histidine, 0.2 M cysteine 2% bovine serum albumin, and 2% human serum albumin) and were found to be nontoxic when evaluated for their cytocompatibility and blood compatibility using periodontal fibroblasts and erythrocytes respectively. Exposure of GNPs to MG-63 cell lines displayed increased percent cell viability (138 ± 27.4) compared to the control group (96 ± 3.7) which confirms its osteoinductive potential. Herein, it can be concluded that the stable, biocompatible and eco-friendly GNPs can be used as an effective bone inductive agent during dental implant therapy.
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U2 - 10.1016/j.msec.2018.08.028
DO - 10.1016/j.msec.2018.08.028
M3 - Article
AN - SCOPUS:85051669734
SN - 0928-4931
VL - 93
SP - 664
EP - 670
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
ER -