Pilot study of salivary butyrylcholinesterase, phosphodiesterase, thiols and cerulopalsmin in auditory neuropathy

Objective: To estimate butyrylcholinesterase (BChE), phosphodiesterase (PDE), thiols and cerulopalsmin by non - invasive means in saliva a of subjects (both cases and controls) and correlated to their hearing sensitivity. Methods: Total of 13 subjects participated in this study. Among them 7 were having auditory neuropathy and 6 were healthy controls. Unstimulated saliva (10 ml) was collected from each participant. Ceruloplasmin, thiols, phosphodiesterase and pseudocholinesterase were estimated by colorimetric method in the salivary samples. Results: Salivary BChE and PDE levels were marginally elevated and protein thiols were marginally decreased in cases as compared to that of controls. Salivary ceruloplasmin was significantly decreased (p = 0.022) in cases as compared to that of controls. Conclusions: Saliva can be used as a potential noninvasive tool for evaluation of disorders.