Piperine-A Major Principle of Black Pepper: A review of its bioactivity and studies

Zorica Stojanović-Radić, Milica Pejčić, Marina Dimitrijević, Ana Aleksić, Nanjangud V. Anil Kumar, Bahare Salehi, William C. Cho, Javad Sharifi-Rad

Research output: Contribution to journalReview articlepeer-review

61 Citations (Scopus)


Piperine is the main compound present in black pepper, and is the carrier of its specific pungent taste, which is responsible for centuries of human dietary utilization and worldwide popularity as a food ingredient. Along with the application as a food ingredient and food preservative, it is used in traditional medicine for many purposes, which has in most cases been justified by modern scientific studies on its biological effects. It has been confirmed that piperine has many bioactive effects, such as antimicrobial action, as well as many physiological effects that can contribute to general human health, including immunomodulatory, hepatoprotective, antioxidant, antimetastatic, antitumor, and many other activities. Clinical studies demonstrated remarkable antioxidant, antitumor, and drug availability-enhancing characteristics of this compound, together with immunomodulatory potential. All these facts point to the therapeutic potential of piperine and the need to incorporate this compound into general health-enhancing medical formulations, as well as into those that would be used as adjunctive therapy in order to enhance the bioavailability of various (chemo)therapeutic drugs.

Original languageEnglish
Article number4270
JournalApplied Sciences (Switzerland)
Issue number20
Publication statusPublished - 01-10-2019

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Instrumentation
  • Engineering(all)
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes


Dive into the research topics of 'Piperine-A Major Principle of Black Pepper: A review of its bioactivity and studies'. Together they form a unique fingerprint.

Cite this