PKa determination of carvedilol by spectrophotometry

Job Herman Berkhout; H. N. Aswatha Ram; Mahalaxmi Rathnanand

doi:10.52711/0974-360X.2021.00478

PKa determination of carvedilol by spectrophotometry

Job Herman Berkhout, H. N. Aswatha Ram, Mahalaxmi Rathnanand

Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Proper knowledge of the pKa value of a compound is of uttermost importance for understanding the behavior of a drug inside the body. The pKa value of Nonselective alpha-1 and beta-blocker Carvedilol shows controversies in literature, whereas values between 7.7 and 8.7 have been previously reported. In this research paper, the pKa value of Carvedilol was re-evaluated using UV-vis spectroscopy. The analytical wavelength used was 241nm. The obtained sigmoid pattern was non-linear fitted using the Boltzmann sigmoidal algorithm. The determined pKa was 7.77 ± 0.09. This value is in accordance with some of the literature publications. Since extensive statistics and multiple replicate experiments were performed, it is assumed that 7.8 is the true pKa value of Carvedilol. Instruments: Digital pH meter MK VI, Systronics Limited, Ahmedabad – 380013, India. UV-Vis spectrophotometer of model UV-2450, Shimadzu Analytical, New Delhi – 110082, India, Cat. No. 208-24301-93.

Original language	English
Pages (from-to)	2714-2716
Number of pages	3
Journal	Research Journal of Pharmacy and Technology
Volume	14
Issue number	5
DOIs	https://doi.org/10.52711/0974-360X.2021.00478
Publication status	Published - 05-2021

All Science Journal Classification (ASJC) codes

Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Pharmacology (medical)

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10.52711/0974-360X.2021.00478

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title = "PKa determination of carvedilol by spectrophotometry",

abstract = "Proper knowledge of the pKa value of a compound is of uttermost importance for understanding the behavior of a drug inside the body. The pKa value of Nonselective alpha-1 and beta-blocker Carvedilol shows controversies in literature, whereas values between 7.7 and 8.7 have been previously reported. In this research paper, the pKa value of Carvedilol was re-evaluated using UV-vis spectroscopy. The analytical wavelength used was 241nm. The obtained sigmoid pattern was non-linear fitted using the Boltzmann sigmoidal algorithm. The determined pKa was 7.77 ± 0.09. This value is in accordance with some of the literature publications. Since extensive statistics and multiple replicate experiments were performed, it is assumed that 7.8 is the true pKa value of Carvedilol. Instruments: Digital pH meter MK VI, Systronics Limited, Ahmedabad – 380013, India. UV-Vis spectrophotometer of model UV-2450, Shimadzu Analytical, New Delhi – 110082, India, Cat. No. 208-24301-93.",

author = "Berkhout, {Job Herman} and {Aswatha Ram}, {H. N.} and Mahalaxmi Rathnanand",

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AU - Rathnanand, Mahalaxmi

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AB - Proper knowledge of the pKa value of a compound is of uttermost importance for understanding the behavior of a drug inside the body. The pKa value of Nonselective alpha-1 and beta-blocker Carvedilol shows controversies in literature, whereas values between 7.7 and 8.7 have been previously reported. In this research paper, the pKa value of Carvedilol was re-evaluated using UV-vis spectroscopy. The analytical wavelength used was 241nm. The obtained sigmoid pattern was non-linear fitted using the Boltzmann sigmoidal algorithm. The determined pKa was 7.77 ± 0.09. This value is in accordance with some of the literature publications. Since extensive statistics and multiple replicate experiments were performed, it is assumed that 7.8 is the true pKa value of Carvedilol. Instruments: Digital pH meter MK VI, Systronics Limited, Ahmedabad – 380013, India. UV-Vis spectrophotometer of model UV-2450, Shimadzu Analytical, New Delhi – 110082, India, Cat. No. 208-24301-93.

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PKa determination of carvedilol by spectrophotometry

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