Plant-derived bioactives and oxidative stress-related disorders: A key trend towards healthy aging and longevity promotion

Bahare Salehi, Elena Azzini, Paolo Zucca, Elena Maria Varoni, Nanjangud V.Anil Kumar, Luciana Dini, Elisa Panzarini, Jovana Rajkovic, Patrick Valere Tsouh Fokou, Ilaria Peluso, Abhay Prakash Mishra, Manisha Nigam, Youssef El Rayess, Marc El Beyrouthy, William N. Setzer, Letizia Polito, Marcello Iriti, Antoni Sureda, Maria Magdalena Quetglas-Llabrés, Miquel MartorellNatália Martins, Mehdi Sharifi-Rad, Leticia M. Estevinho, Javad Sharifi-Rad

Research output: Contribution to journalReview articlepeer-review

84 Citations (Scopus)


Plants and their corresponding botanical preparations have been used for centuries due to their remarkable potential in both the treatment and prevention of oxidative stress-related disorders. Aging and aging-related diseases, like cardiovascular disease, cancer, diabetes, and neurodegenerative disorders, which have increased exponentially, are intrinsically related with redox imbalance and oxidative stress. Hundreds of biologically active constituents are present in each whole plant matrix, providing promissory bioactive effects for human beings. Indeed, the worldwide population has devoted increased attention and preference for the use of medicinal plants for healthy aging and longevity promotion. In fact, plant-derived bioactives present a broad spectrum of biological effects, and their antioxidant, anti-inflammatory, and, more recently, anti-aging effects, are considered to be a hot topic among the medical and scientific communities. Nonetheless, despite the numerous biological effects, it should not be forgotten that some bioactive molecules are prone to oxidation and can even exert pro-oxidant effects. In this sense, the objective of the present review is to provide a detailed overview of plant-derived bioactives in age-related disorders. Specifically, the role of phytochemicals as antioxidants and pro-oxidant agents is carefully addressed, as is their therapeutic relevance in longevity, aging-related disorders, and healthy-aging promotion. Finally, an eye-opening look into the overall evidence of plant compounds related to longevity is present.

Original languageEnglish
Article number947
JournalApplied Sciences (Switzerland)
Issue number3
Publication statusPublished - 01-02-2020

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Instrumentation
  • Engineering(all)
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes


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