Plasma proteinase inhibitory activity in ectopic and molar pregnancy

Maya Roche, V. P. Arun Kumar, S. M. Ibrahim, K. Nalini

Research output: Contribution to journalArticlepeer-review


Antitryptic, antichymotryptic and alpha 2- macroglobulin activities were measured in sera of normal nonpregnant and normal pregnant women and women with tubal ectopic pregnancy and molar pregnancies in the first 5 to 7 weeks of pregnancy calculated from the last menstrual period . While alpha 2- macroglobulin decreased in early normal pregnancy compared to nonpregnant state (p < 0.001), in ectopic and molar pregnancies there was an increase in alpha 2- macroglobulin activity (p < 0.001), as compared to nonpregnant and normal pregnant women . Antitryptic activity did not increase in normal and ectopic pregnancy, however was increased in molar pregnancy (p < 0.01). Antichymotryptic activities did not show a change either in normal pregnancy or in cases of ectopic and molar pregnancy . Drop in alpha 2- macroglobulin activity to near normal levels in ectopic, 6 weeks post surgery, correlated well with the decrease in β-hCG. However, in molar pregnancy, alpha 2- macroglobulin remained elevated even when the β-hCG levels in serum returned to zero 10 weeks after surgery. The studies suggest a major role for circulating proteinase inhibitors especially alpha 2-macroglobulin in regulating proteinase activity in normal, ectopic and molar pregnancy.

Original languageEnglish
Pages (from-to)352-355
Number of pages4
JournalIndian Journal of Clinical Biochemistry
Issue number4
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry


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