TY - JOUR
T1 - Pleural tuberculosis following infliximab therapy for ankylosing spondylitis
AU - Gokul Krishnan, V.
AU - Madhyastha, Sharath
AU - Ramamoorthi, Kusugodlu
AU - Acharya, Raviraj
AU - Gopalaswamy, Vinaya
PY - 2017/1/1
Y1 - 2017/1/1
N2 - We present a case of pleural tuberculosis (TB) in a patient on infliximab for ankylosing spondylitis. A 36-year-old male presented to our hospital with low back ache of inflammatory type along with multiple symmetric inflammatory type of joint pain. Further clinical examination, laboratory and radiological investigations were suggestive of ankylosing spondylitis. He was initially treated with nonsteroidal anti-inflammatory drugs but citing poor response it was decided to initiate biologic therapy using infliximab (antitumor necrosis factor-alpha). Mantoux test and chest radiograph were done before the therapy to rule out TB. Following three doses of infliximab, patient came with complaints of fever and cough for 1 week. On investigation, it was found to be a case of pulmonary TB. This shows the importance of close monitoring of patient for TB among patients on infliximab even though the screening test has come out to be negative.
AB - We present a case of pleural tuberculosis (TB) in a patient on infliximab for ankylosing spondylitis. A 36-year-old male presented to our hospital with low back ache of inflammatory type along with multiple symmetric inflammatory type of joint pain. Further clinical examination, laboratory and radiological investigations were suggestive of ankylosing spondylitis. He was initially treated with nonsteroidal anti-inflammatory drugs but citing poor response it was decided to initiate biologic therapy using infliximab (antitumor necrosis factor-alpha). Mantoux test and chest radiograph were done before the therapy to rule out TB. Following three doses of infliximab, patient came with complaints of fever and cough for 1 week. On investigation, it was found to be a case of pulmonary TB. This shows the importance of close monitoring of patient for TB among patients on infliximab even though the screening test has come out to be negative.
UR - http://www.scopus.com/inward/record.url?scp=85016613072&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85016613072&partnerID=8YFLogxK
U2 - 10.4103/jpp.JPP_174_16
DO - 10.4103/jpp.JPP_174_16
M3 - Article
AN - SCOPUS:85016613072
SN - 0976-500X
VL - 8
SP - 41
EP - 43
JO - Journal of Pharmacology and Pharmacotherapeutics
JF - Journal of Pharmacology and Pharmacotherapeutics
IS - 1
ER -