Plumbagin-loaded PLGA microspheres with reduced toxicity and enhanced antitumour efficacy in mice

U. V. Singh; K. S. Bisht; S. Rao; P. U. Devi; N. Udupa

Plumbagin-loaded PLGA microspheres with reduced toxicity and enhanced antitumour efficacy in mice

U. V. Singh, K. S. Bisht, S. Rao, P. U. Devi, N. Udupa^*

^*Corresponding author for this work

Department of Radiation Biology and Toxicology, Manipal School of Life Sciences, Manipal
Department of Pharmacy Management, Manipal College of Pharmaceutical Sciences, Manipal
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Plumbagin was encapsulated in microspheres using poly(D,L-lactide)-co-glycolide (PLGA) (50:50). The in-vitro release profile was triphasic suggesting different drug release mechanisms. The release of the drug could be controlled for about four weeks. The toxicity of plumbagin was reduced in mice after subcutaneous injection when it was encapsulated in microspheres. The volume doubling time of PLGA-loaded microspheres was significantly higher compared with the plain drug in sarcoma-180 tumour.

Original language	English
Pages (from-to)	407-409
Number of pages	3
Journal	Pharmaceutical Sciences
Volume	2
Issue number	9
Publication status	Published - 1996

All Science Journal Classification (ASJC) codes

Pharmaceutical Science

Cite this

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title = "Plumbagin-loaded PLGA microspheres with reduced toxicity and enhanced antitumour efficacy in mice",

abstract = "Plumbagin was encapsulated in microspheres using poly(D,L-lactide)-co-glycolide (PLGA) (50:50). The in-vitro release profile was triphasic suggesting different drug release mechanisms. The release of the drug could be controlled for about four weeks. The toxicity of plumbagin was reduced in mice after subcutaneous injection when it was encapsulated in microspheres. The volume doubling time of PLGA-loaded microspheres was significantly higher compared with the plain drug in sarcoma-180 tumour.",

author = "Singh, {U. V.} and Bisht, {K. S.} and S. Rao and Devi, {P. U.} and N. Udupa",

year = "1996",

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journal = "Pharmaceutical Sciences",

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T1 - Plumbagin-loaded PLGA microspheres with reduced toxicity and enhanced antitumour efficacy in mice

AU - Singh, U. V.

AU - Bisht, K. S.

AU - Rao, S.

AU - Devi, P. U.

AU - Udupa, N.

PY - 1996

Y1 - 1996

N2 - Plumbagin was encapsulated in microspheres using poly(D,L-lactide)-co-glycolide (PLGA) (50:50). The in-vitro release profile was triphasic suggesting different drug release mechanisms. The release of the drug could be controlled for about four weeks. The toxicity of plumbagin was reduced in mice after subcutaneous injection when it was encapsulated in microspheres. The volume doubling time of PLGA-loaded microspheres was significantly higher compared with the plain drug in sarcoma-180 tumour.

AB - Plumbagin was encapsulated in microspheres using poly(D,L-lactide)-co-glycolide (PLGA) (50:50). The in-vitro release profile was triphasic suggesting different drug release mechanisms. The release of the drug could be controlled for about four weeks. The toxicity of plumbagin was reduced in mice after subcutaneous injection when it was encapsulated in microspheres. The volume doubling time of PLGA-loaded microspheres was significantly higher compared with the plain drug in sarcoma-180 tumour.

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AN - SCOPUS:0030319595

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ER -

Plumbagin-loaded PLGA microspheres with reduced toxicity and enhanced antitumour efficacy in mice

Abstract

All Science Journal Classification (ASJC) codes

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