TY - JOUR
T1 - Polymeric microneedles for transdermal delivery of nanoparticles
T2 - Frontiers of formulation, sterility and stability aspects
AU - Salwa,
AU - Chevala, Naga Thirumalesh
AU - Jitta, Srinivas Reddy
AU - Marques, Shirleen Miriam
AU - Vaz, Vanessa Marcia
AU - Kumar, Lalit
N1 - Funding Information:
Biodegradable polymers, after administration, undergo degradation in the skin and release the incorporated nanocarriers. This release can be sustained for longer periods of time, even for months and hence MNs made out of these polymers are administered for a long duration to ensure the degradation property [109]. These polymers can be synthetic like PLA, PLGA, PGA [99] and PCL [110] or natural like chitin [111] and chitosan [112]. Li et al. fabricated MN patches of levonorgesterol made from PLGA and PLA which sustained the drug release for more than one month. While PLGA controlled the drug release, PLA provided added mechanical strength to the MNs [113]. Polymers having two different release profiles have been examined to fabricate MNs. One study fabricated MNs with a dissolvable tip of PVP and the rest of the needle comprised of biodegradable PLGA microparticles, both containing the drug. First, there was a rapid release of the drug from the tip, subsequently by prolonged drug release for several days [86]. Another similar study incorporated drug loaded PLGA as the tips for controlled release and drug loaded rapidly dissolving PVP in the rest of the needle. Chen et al. fabricated patches comprising of ovalbumin loaded chitosan MNs. The supporting array of the patch comprised of PVA/PVP for providing added strength and rapid dissolution after insertion. After the dissolution of the supporting array, the MNs in the skin provided sustained release of the antigen for up to 28 days [112]. One disadvantage of chitosan is its low aqueous solubility at neutral pH which can be addressed by formulating water soluble chitosan by acid hydrolysis. The MNs fabricated using water soluble chitosan demonstrated adequate mechanical properties and showed prolonged release [114].Authors would like to sincerely thank All India Council for Technical Education (AICTE), New Delhi (India) for providing National Doctoral Fellowship to Salwa; Indian Council for Medical Research (ICMR), New Delhi (India) for providing Senior Research Fellowship to Naga Thirumalesh Chevala and Jitta Srinivas Reddy; Indian Council for Medical Research (ICMR), New Delhi (India) for also providing financial support to work in this area of research; and Manipal Academy of Higher Education, Manipal (India) for providing Dr. TMA Pai fellowship to Shirleen Marques. We also extend our gratitude to Manipal College of Pharmaceutical Sciences, Manipal (India) for their constant support round the clock.
Funding Information:
Authors would like to sincerely thank All India Council for Technical Education ( AICTE ), New Delhi (India) for providing National Doctoral Fellowship to Salwa; Indian Council for Medical Research ( ICMR ), New Delhi (India) for providing Senior Research Fellowship to Naga Thirumalesh Chevala and Jitta Srinivas Reddy; Indian Council for Medical Research ( ICMR ), New Delhi (India) for also providing financial support to work in this area of research; and Manipal Academy of Higher Education, Manipal (India) for providing Dr. TMA Pai fellowship to Shirleen Marques. We also extend our gratitude to Manipal College of Pharmaceutical Sciences, Manipal (India) for their constant support round the clock.
Publisher Copyright:
© 2021
PY - 2021/10
Y1 - 2021/10
N2 - With the launch of few products in the market, transdermal drug delivery through microneedles (MNs) has evidenced a major leap. Interest in MNs is growing exponentially as it overcomes the limitations accompanying other delivery routes. Among the various types of MNs, polymeric microneedles (PMNs) seem to be more propitious because of the associated favourable innate properties. Nevertheless, struggle in loading capacity, unmanageable rate of drug release, and monotonic curative approach hampers the further development of PMNs. Recent emerging research has drawn inspiration from nanocarriers and in conjunction with PMNs have opened up new perspectives for the treatment of various diseases. In this review, we focus on recent progresses in the field of transdermal drug delivery using nano carriers in conjunction with PMNs for various therapeutic and diagnostic activities. Additionally, we describe the various factors impacting drug delivery, and challenges involved in sterilization and stability aspects associated with nanocarrier loaded PMNs, highlighting future research perspectives alongside.
AB - With the launch of few products in the market, transdermal drug delivery through microneedles (MNs) has evidenced a major leap. Interest in MNs is growing exponentially as it overcomes the limitations accompanying other delivery routes. Among the various types of MNs, polymeric microneedles (PMNs) seem to be more propitious because of the associated favourable innate properties. Nevertheless, struggle in loading capacity, unmanageable rate of drug release, and monotonic curative approach hampers the further development of PMNs. Recent emerging research has drawn inspiration from nanocarriers and in conjunction with PMNs have opened up new perspectives for the treatment of various diseases. In this review, we focus on recent progresses in the field of transdermal drug delivery using nano carriers in conjunction with PMNs for various therapeutic and diagnostic activities. Additionally, we describe the various factors impacting drug delivery, and challenges involved in sterilization and stability aspects associated with nanocarrier loaded PMNs, highlighting future research perspectives alongside.
UR - http://www.scopus.com/inward/record.url?scp=85110147058&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85110147058&partnerID=8YFLogxK
U2 - 10.1016/j.jddst.2021.102711
DO - 10.1016/j.jddst.2021.102711
M3 - Review article
AN - SCOPUS:85110147058
SN - 1773-2247
VL - 65
JO - Journal of Drug Delivery Science and Technology
JF - Journal of Drug Delivery Science and Technology
M1 - 102711
ER -