Potential role of Vitamin C as an Antioxidant on Bisphenol (BPA) Induced Oxidative Stress in Wistar rats

Sumit Kumar, Rekha D. Kini, Nayanatara Arun Kumar, Megha Gokul, M. Vivek Pai, Shyamala Nayak

Research output: Contribution to journalArticlepeer-review


Introduction: Bisphenol A (BPA) is considered one of the most common industrial manufactured chemicals. Vitamin C is an important dietary antioxidant which significantly decreases the adverse effects of reactive oxygen species. Objective of the study: To evaluate the damaging effect of Bisphenol on testes and the role of vitamin C on Bisphenol induced testicular damage. Materials and Methods: Institutional ethics committee clearance was obtained before beginning the experiments. Animals were divided into the following groups with 6 rats in each group; Group 1: Control Group (Olive oil treated) Group 2: (Vitamin C treated), Group 3: (Bispenol treated), Group 4: (Vitamin C + Bispenol treated). Testicular tissue was processed to measure MDA and GSH level, sperm count and sperm morphology, histology. Serum level of testosterone was estimated. Results: Results of the present study showed a significant decrease in the level of GSH and sperm count and testosterone level and increase in MDA in Group 3 compared to GR.1and GR.2. Pre-treatment with Vitamin C showed an increase in the level of GSH and testosterone as well as sperm count compared to Bisphenol treated rats. Histological results were supported the biochemical results. Vitamin C also showed decrease in sperm shape abnormality which was induced by Bisphenol intoxication. Conclusion: Thus we have hypothesized that vitamin C could act as an antioxidant against BPA induced oxidative stress.

Original languageEnglish
Pages (from-to)2142-2146
Number of pages5
JournalResearch Journal of Pharmacy and Technology
Issue number5
Publication statusPublished - 05-2023

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
  • Pharmacology (medical)


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