Preoperative levosimendan in ischemic mitral valve repair

Pranav Sharma, Amber Malhotra, Sanjay Gandhi, Pankaj Garg, Arvind Bishnoi, Hemang Gandhi

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Background: Levosimendan is a new calcium sensitizing drug with vasodilatory and inotropic properties, which is used for the treatment of postoperative low cardiac output syndrome and difficult weaning from cardiopulmonary bypass. Objective: To evaluate the hemodynamic effects of levosimendan during and after coronary artery bypass grafting on cardiopulmonary bypass and mitral valve repair in patients with low left ventricular ejection fractions (<30%). Methods: 40 patients were enrolled in this double-blind prospective randomized controlled trial. They received either levosimendan or a placebo preoperatively (n=20) for 24 h. Clinical parameters were measured before and after administration. Any adverse events during and after drug administration and postoperative complications were evaluated. Results: Patients treated with levosimendan exhibited a higher cardiac index and mean arterial pressure intraoperative and in the early postoperative period, compared to the control group. Patients treated with levosimendan required less ventilatory support (p<0.0001) and had shorter intensive care unit (p<0.0001) and hospital stay (p<0.0001). Conclusions: Preoperative treatment with levosimendan in patients undergoing coronary artery bypass grafting and mitral valve repair resulted in improved hemodynamics and a stable postoperative course.

Original languageEnglish
Pages (from-to)539-545
Number of pages7
JournalAsian Cardiovascular and Thoracic Annals
Issue number5
Publication statusPublished - 06-2014

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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