TY - JOUR
T1 - Preparation and evaluation of nano-vesicles of brimonidine tartrate as an ocular drug delivery system
AU - Prabhu, P.
AU - Kumar, Nitish R.
AU - Koland, M.
AU - Harish, N. M.
AU - Vijayanarayan, K.
AU - Dhondge, G.
AU - Charyulu, R. N.
N1 - Funding Information:
The authors wish to acknowledge Nitte University, Mangalore (Karnataka) India, for providing the necessary facilities and financial support to carry out this project under the ‘Student Research Grant’ Programme of the University. The authors are also thankful to Manipal College of Pharmaceutical Sciences, Manipal, for providing the necessary facilities to carry out some investigations.
PY - 2010
Y1 - 2010
N2 - The objective of the present investigation was to design a vesicular formulation of brimonidine tartrate and evaluate its ability to reduce the dosing frequency and improve the therapeutic efficacy of the drug. Nano-vesicles of brimonidine tartrate were prepared by film hydration method. The prepared vesicles were evaluated for photomicroscopic characteristics, entrapment efficiency, in vitro, and ex-in vitro drug release and in vivo intraocular pressure (IOP) lowering activity. The methods employed for preparation of vesicles produced nano vesicles of acceptable shape and size. The in vitro, and ex-in vitro drug release studies showed that there was slow and prolonged release of the drug, which followed zero-order kinetics. The IOP-lowering activity of nano vesicles was determined and compared with that of pure drug solution and showed that the IOP-lowering action of nano-vesicles sustained for a longer period of time. Stability studies revealed that the vesicle formulations were stable at the temperature range of 2-8C, with no change in shape and drug content. The results of the study indicate that it is possible to develop a safe and physiologically effective topical formulation that is also convenient for patients.
AB - The objective of the present investigation was to design a vesicular formulation of brimonidine tartrate and evaluate its ability to reduce the dosing frequency and improve the therapeutic efficacy of the drug. Nano-vesicles of brimonidine tartrate were prepared by film hydration method. The prepared vesicles were evaluated for photomicroscopic characteristics, entrapment efficiency, in vitro, and ex-in vitro drug release and in vivo intraocular pressure (IOP) lowering activity. The methods employed for preparation of vesicles produced nano vesicles of acceptable shape and size. The in vitro, and ex-in vitro drug release studies showed that there was slow and prolonged release of the drug, which followed zero-order kinetics. The IOP-lowering activity of nano vesicles was determined and compared with that of pure drug solution and showed that the IOP-lowering action of nano-vesicles sustained for a longer period of time. Stability studies revealed that the vesicle formulations were stable at the temperature range of 2-8C, with no change in shape and drug content. The results of the study indicate that it is possible to develop a safe and physiologically effective topical formulation that is also convenient for patients.
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U2 - 10.4103/0975-1483.71623
DO - 10.4103/0975-1483.71623
M3 - Article
AN - SCOPUS:78650447564
SN - 0975-1483
VL - 2
SP - 356
EP - 361
JO - Journal of Young Pharmacists
JF - Journal of Young Pharmacists
IS - 4
ER -