TY - JOUR
T1 - Preparation of mucoadhesive microspheres for nasal delivery by spray drying
AU - Rathananand, M.
AU - Kumar, D.
AU - Shirwaikar, A.
AU - Kumar, R.
AU - Sampath Kumar, D.
AU - Prasad, R.
N1 - Cited By :16
Export Date: 10 November 2017
CODEN: IJSID
Correspondence Address: Rathananand, M.; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal - 576 104, India; email: [email protected]
Chemicals/CAS: alginic acid, 28961-37-7, 29894-36-8, 9005-32-7, 9005-38-3; chitosan, 9012-76-4; hydroxypropylcellulose, 9004-64-2; hydroxypropylmethylcellulose, 9004-65-3; levocetirizine, 130018-77-8
Manufacturers: symed laboratory, India
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PY - 2007
Y1 - 2007
N2 - In this study the suitability of spray drying as a method for the formulation of mucoadhesive microspheres for nasal delivery was evaluated. The microspheres were produced from mucoadhesive polymers including chitosan salt, hydroxypropylmethylcellulose, hydroxypropylcellulose, sodium alginate and contained levocetirizine dihydrochloride as the model drug. The microspheres formed were evaluated for particle size distribution, drug loading, production yield, in vitro release characteristics and suitability for nasal drug delivery in terms of particle size and release properties. The conditions of the spray dryer were optimized for production yield and particle size.
AB - In this study the suitability of spray drying as a method for the formulation of mucoadhesive microspheres for nasal delivery was evaluated. The microspheres were produced from mucoadhesive polymers including chitosan salt, hydroxypropylmethylcellulose, hydroxypropylcellulose, sodium alginate and contained levocetirizine dihydrochloride as the model drug. The microspheres formed were evaluated for particle size distribution, drug loading, production yield, in vitro release characteristics and suitability for nasal drug delivery in terms of particle size and release properties. The conditions of the spray dryer were optimized for production yield and particle size.
M3 - Article
SN - 0250-474X
VL - 69
SP - 651
EP - 657
JO - Indian Journal of Pharmaceutical Sciences
JF - Indian Journal of Pharmaceutical Sciences
IS - 5
ER -