Primary Ampullary Adenosquamous carcinoma: Report of two cases

Bhavna Nayal, Varun Kumar Singh, Swati Sharma, S. Archana, Ramchandra Bhat

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Introduction: Adenosquamous carcinoma of the ampulla of Vater is a rare neoplasm with its clinicopathological profile limited to a few case reports. Here we report clinical profile, morphology and outcome of two cases of this rare entity. Case report: Case 1 was a 57 year old male who presented with features of obstructive jaundice; Case 2 was a 55 year old female with complaints of pain abdomen. Imaging studies suggested a pre-emptive diagnosis if periampullary malignancy for which both patients underwent Whipple's pancreaticoduodenectomy. Histopathological examination revealed an ampullary malignancy with variable proportions of adenocarcinoma and squamous cell carcinoma. Case 2 also showed concurrent region lymph node metastasis. Case 1was alive at 15months follow up with no recurrence/metastasis while case 2 survived for only 10 days post surgery. Conclusion: Adenosquamous carcinoma occurring at the ampulla of Vater is a rare event with less than 15 cases documented in the English literature so far. It is an aggressive tumour and is associated with a dismal prognosis. Here we add two more cases to the literature for better understanding of the clinicopathological profile, prognostic indicators and clinical outcome of this rare neoplasm.

Original languageEnglish
Article number11
JournalOnline Journal of Health and Allied Sciences
Issue number2
Publication statusPublished - 01-04-2018

All Science Journal Classification (ASJC) codes

  • Medicine(all)


Dive into the research topics of 'Primary Ampullary Adenosquamous carcinoma: Report of two cases'. Together they form a unique fingerprint.

Cite this